SPTBN1 and PJA1

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SPTBN1	PJA1
Description		spectrin beta, non-erythrocytic 1	praja ring finger ubiquitin ligase 1
Image
GO Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Spectrin Spectrin-associated Cytoskeleton Axolemma M Band Extracellular Exosome	Cytoplasm
	Molecular Function	RNA Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Phospholipid Binding Ankyrin Binding Cadherin Binding GTPase Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	MAPK Cascade Mitotic Cytokinesis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Plasma Membrane Organization Cytoskeleton Organization Axon Guidance Positive Regulation Of Interleukin-2 Production Golgi To Plasma Membrane Protein Transport Actin Filament Capping Membrane Assembly Protein Localization To Plasma Membrane Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane	Protein Ubiquitination Protein Catabolic Process
Pathways		Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Calcium 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS		Basophil percentage of white cells ( 32888494) Bone mineral density (spine) ( 19079262 19801982 18445777) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chronic kidney disease ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Fractures ( 30158200) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) HOMA-B (corrected for HOMA-IR) ( 30369944) Intraocular pressure ( 29617998 29785010 31959993 30054594 30591961) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean platelet volume ( 32888494) Myopia (pathological) ( 22685421) Neutrophil count ( 32888494) Pars triangularis volume ( 31530798) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Urate levels ( 31578528) White blood cell count ( 32888494)	Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		49 interacting genes: ACTR1A ANK2 APC ATF7IP CAPN1 CDC5L CEP63 COPB1 CPNE1 CPNE4 CSNK2A1 CTNNA1 EIF3H EPB41 EPB41L3 GOLGA6L10 GRB2 GRIA2 HSPB1 MAPK14 MEF2C NF2 NOP53 PACSIN1 PJA1 PLCB1 PLEKHA5 PRKACA PTEN PYGO1 RINT1 SEPTIN8 SH3BP5 SMAD3 SMAD4 SMAD9 SNAPIN SNCA SPTAN1 SREBF2 STAT1 STXBP1 SUMO2 THAP3 TNIK TRAF3IP1 YWHAG ZNF251 ZNF512B	64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3A GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440
Entrez ID		6711	64219
HPRD ID		01683	02335
Ensembl ID		ENSG00000115306	ENSG00000181191
Uniprot IDs		B2ZZ89 Q01082	Q8NG27
PDB IDs		1AA2 1BKR 3EDV	2L0B
Enriched GO Terms of Interacting Partners?
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