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SFRP4 and AP2M1
Data Source:
BioGRID
(two hybrid)
SFRP4
AP2M1
Description
secreted frizzled related protein 4
adaptor related protein complex 2 subunit mu 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Cytoplasm
Cell Surface
Lysosomal Membrane
Cytosol
Plasma Membrane
Clathrin-coated Pit
AP-2 Adaptor Complex
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Cytoplasmic Vesicle
Endolysosome Membrane
Intracellular Membrane-bounded Organelle
Clathrin-coated Endocytic Vesicle
Extracellular Exosome
Molecular Function
Protein Binding
Wnt-protein Binding
Signal Sequence Binding
Protein Binding
Lipid Binding
Clathrin Adaptor Activity
Ion Channel Binding
Low-density Lipoprotein Particle Receptor Binding
Biological Process
Positive Regulation Of Receptor Internalization
Negative Regulation Of Cell Population Proliferation
Response To Hormone
Positive Regulation Of Gene Expression
Cell Differentiation
Negative Regulation Of Wnt Signaling Pathway
Regulation Of BMP Signaling Pathway
Non-canonical Wnt Signaling Pathway
Positive Regulation Of Apoptotic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Epidermal Cell Differentiation
Phosphate Ion Homeostasis
Canonical Wnt Signaling Pathway
Bone Morphogenesis
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Keratinocyte Apoptotic Process
Negative Regulation Of Non-canonical Wnt Signaling Pathway
Negative Regulation Of Sodium-dependent Phosphate Transport
Intracellular Protein Transport
Endocytosis
Vesicle Budding From Membrane
Vesicle-mediated Transport
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Receptor Internalization
Low-density Lipoprotein Particle Receptor Catabolic Process
Low-density Lipoprotein Particle Clearance
Cellular Protein-containing Complex Assembly
Ephrin Receptor Signaling Pathway
Regulation Of Defense Response To Virus By Virus
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Membrane Organization
Clathrin-dependent Endocytosis
Regulation Of Vesicle Size
Negative Regulation Of Protein Localization To Plasma Membrane
Pathways
Nef mediated downregulation of CD28 cell surface expression
Nef Mediated CD4 Down-regulation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
Nef Mediated CD8 Down-regulation
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Recycling pathway of L1
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance
Potential therapeutics for SARS
Drugs
Cyclothiazide
Perindopril
Diseases
GWAS
Blood protein levels (
30072576
)
Dupuytren's disease (
28886342
21732829
)
Heel bone mineral density (
30598549
28869591
)
Major depressive disorder (
22472876
)
Interacting Genes
21 interacting genes:
AP2M1
AQP6
AURKA
BMPR1A
BUB1
CDKN2A
CKMT1B
CTNNA1
DLC1
ERBB2
HSD17B11
MCC
NARF
NRAS
PDGFRL
PFKM
PIK3CA
PMS2
PTPN12
PTPRJ
SMAD4
76 interacting genes:
ADRA1B
AGTR1
AP2B1
AQP4
ARRB2
ATXN1L
BDKRB2
C1orf35
CACNA1A
CD22
CD3D
CDK11B
CORO7
CSNK2B
CTLA4
CXorf51A
CXorf51B
DAB2
DCX
DPPA2
DVL2
EAF1
EHD2
EIF1AD
FAM90A1
FURIN
FXR2
GAK
GRIN2B
H2BC10
H2BC13
H2BC21
H2BC4
H2BC6
H2BC7
H2BC8
HEXIM2
HTR6
IKZF1
KCNJ11
KNOP1
LAMP1
LTB4R2
LY9
MAB21L3
MED4
MEGF10
MFAP1
MPP1
MTURN
NAA11
NCOR2
NDRG1
NKAPD1
PRPF18
PRPF38A
PRR13
PTS
RALBP1
RNF111
RPL22
RPL38
RRP12
RSPH14
RUNDC3A
SFRP4
STON2
SYNJ1
TASOR
TBC1D5
TGOLN2
TMA16
UBC
UTP25
ZBTB8A
ZNF581
Entrez ID
6424
1173
HPRD ID
07357
03014
Ensembl ID
ENSG00000106483
ENSG00000161203
Uniprot IDs
Q6FHJ7
B4DNB9
E9PFW3
Q96CW1
PDB IDs
1H6E
6BNT
6URI
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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