RPA1 and HSPA6

Data Source:
BioGRID (two hybrid)

		RPA1	HSPA6
Description		replication protein A1	heat shock protein family A (Hsp70) member 6
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm DNA Replication Factor A Complex PML Body Site Of DNA Damage	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane COP9 Signalosome Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Single-stranded Telomeric DNA Binding Metal Ion Binding G-rich Strand Telomeric DNA Binding	Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication DNA-dependent DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair DNA Recombination Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomerase Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision Protein Localization To Chromosome Interstrand Cross-link Repair Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Meiotic Cell Cycle Error-free Translesion Synthesis Regulation Of Cellular Response To Heat Regulation Of Signal Transduction By P53 Class Mediator	Response To Unfolded Protein Vesicle-mediated Transport Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Neutrophil Degranulation Chaperone Cofactor-dependent Protein Refolding Cellular Heat Acclimation
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress SUMOylation of DNA damage response and repair proteins Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination	Regulation of HSF1-mediated heat shock response Neutrophil degranulation
Drugs
Diseases
GWAS		Airway imaging phenotypes ( 26030696) Bipolar disorder ( 31043756) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)	Birth weight ( 31043758) Blood protein levels ( 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 28067908 23128233) Offspring birth weight ( 31043758) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		68 interacting genes: AICDA AKTIP ANXA1 ANXA7 ASCC2 ATM BID BLM BRCA2 BRIP1 CCNA1 CCNA2 CCNB1 CDC5L CPE CSNK2B DMC1 EHMT2 ERCC1 ERCC4 EXO5 GNB5 HAX1 HELB HGH1 HNRNPUL1 HSPA6 HUS1 MCM2 MCM4 MCM6 MCM7 MMS22L MSH4 MTUS2 MUTYH ORC2 ORC6 PAXIP1 PCNA POLL PRIMPOL PRKDC RAD1 RAD23B RAD51 RAD52 RAD9A RBM23 RCC1 RECQL RFWD3 RPA2 RPA3 RPA4 RPS6KA5 SELENBP1 SEM1 SMAD3 TCEA2 TK1 TP53 TREX1 VIM WRN XPA XPC ZBTB14	16 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FLNA KRT222 LGALS7 LGALS7B PPIB PRAP1 RPA1 TERF1
Entrez ID		6117	3310
HPRD ID		01565	00775
Ensembl ID		ENSG00000132383	ENSG00000173110
Uniprot IDs		P27694	A0A384NKX5 B3KSM6 P17066
PDB IDs		1EWI 1FGU 1JMC 1L1O 2B29 2B3G 4IJH 4IJL 4IPC 4IPD 4IPG 4IPH 4LUO 4LUV 4LUZ 4LW1 4LWC 4NB3 4O0A 4R4C 4R4I 4R4O 4R4Q 4R4T 5E7N 5EAY 5N85 5N8A	3FE1
Enriched GO Terms of Interacting Partners?
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