RPA1 and BID

Data Source:
BioGRID (pull down, affinity chromatography technology)

		RPA1	BID
Description		replication protein A1	BH3 interacting domain death agonist
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm DNA Replication Factor A Complex PML Body Site Of DNA Damage	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Integral Component Of Mitochondrial Membrane
	Molecular Function	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Single-stranded Telomeric DNA Binding Metal Ion Binding G-rich Strand Telomeric DNA Binding	Death Receptor Binding Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication DNA-dependent DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair DNA Recombination Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomerase Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision Protein Localization To Chromosome Interstrand Cross-link Repair Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Meiotic Cell Cycle Error-free Translesion Synthesis Regulation Of Cellular Response To Heat Regulation Of Signal Transduction By P53 Class Mediator	Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Mitochondrial Changes Positive Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein-containing Complex Assembly Regulation Of Cell Population Proliferation Signal Transduction In Response To DNA Damage Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Neuron Apoptotic Process Protein-containing Complex Assembly Establishment Of Protein Localization To Membrane Positive Regulation Of Release Of Cytochrome C From Mitochondria Hepatocyte Apoptotic Process Mitochondrial Outer Membrane Permeabilization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress SUMOylation of DNA damage response and repair proteins Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination	Activation of BAD and translocation to mitochondria Activation and oligomerization of BAK protein BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation, translocation and oligomerization of BAX TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation, myristolyation of BID and translocation to mitochondria
Drugs
Diseases
GWAS		Airway imaging phenotypes ( 26030696) Bipolar disorder ( 31043756) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)	Adult body size ( 32376654) Diisocyanate-induced asthma ( 25918132) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		68 interacting genes: AICDA AKTIP ANXA1 ANXA7 ASCC2 ATM BID BLM BRCA2 BRIP1 CCNA1 CCNA2 CCNB1 CDC5L CPE CSNK2B DMC1 EHMT2 ERCC1 ERCC4 EXO5 GNB5 HAX1 HELB HGH1 HNRNPUL1 HSPA6 HUS1 MCM2 MCM4 MCM6 MCM7 MMS22L MSH4 MTUS2 MUTYH ORC2 ORC6 PAXIP1 PCNA POLL PRIMPOL PRKDC RAD1 RAD23B RAD51 RAD52 RAD9A RBM23 RCC1 RECQL RFWD3 RPA2 RPA3 RPA4 RPS6KA5 SELENBP1 SEM1 SMAD3 TCEA2 TK1 TP53 TREX1 VIM WRN XPA XPC ZBTB14	37 interacting genes: AHCYL1 BAK1 BAX BCL2 BCL2A1 BCL2L1 BCL2L2 CAPN1 CAPN2 CASP1 CASP10 CASP2 CASP3 CASP8 CRMP1 CRNKL1 CSNK1A1 CSNK1E CSNK2A1 CSNK2A2 CSNK2B DDIT4L ERG28 FBN3 GAPDH GBP2 GZMB MCL1 PLEKHM1 RBM48 REL RPA1 SETDB1 TLE1 TUBB2B YWHAB ZHX1
Entrez ID		6117	637
HPRD ID		01565	03590
Ensembl ID		ENSG00000132383	ENSG00000015475
Uniprot IDs		P27694	A8ASI8 B2ZP79 B3KT21 P55957
PDB IDs		1EWI 1FGU 1JMC 1L1O 2B29 2B3G 4IJH 4IJL 4IPC 4IPD 4IPG 4IPH 4LUO 4LUV 4LUZ 4LW1 4LWC 4NB3 4O0A 4R4C 4R4I 4R4O 4R4Q 4R4T 5E7N 5EAY 5N85 5N8A	1ZY3 2BID 2KBW 2M5B 2M5I 4BD2 4QVE 4ZEQ 4ZIG 4ZII 5AJJ 5C3F
Enriched GO Terms of Interacting Partners?
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