HSPA6 and BAG4

Data Source:
BioGRID (two hybrid)

		HSPA6	BAG4
Description		heat shock protein family A (Hsp70) member 6	BAG cochaperone 4
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane COP9 Signalosome Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding	Adenyl-nucleotide Exchange Factor Activity RNA Binding Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Chaperone Binding
	Biological Process	Response To Unfolded Protein Vesicle-mediated Transport Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Neutrophil Degranulation Chaperone Cofactor-dependent Protein Refolding Cellular Heat Acclimation	Protein Folding Positive Regulation Of Fibroblast Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion Protein Stabilization Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Kinase B Signaling Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Protein Localization To Plasma Membrane Negative Regulation Of MRNA Modification Ruffle Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity
Pathways		Regulation of HSF1-mediated heat shock response Neutrophil degranulation	Regulation of HSF1-mediated heat shock response Signaling by FGFR1 in disease TNF signaling Signaling by plasma membrane FGFR1 fusions
Drugs
Diseases
GWAS		Birth weight ( 31043758) Blood protein levels ( 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 28067908 23128233) Offspring birth weight ( 31043758) Ulcerative colitis ( 28067908 21297633)	Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)
Interacting Genes		16 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FLNA KRT222 LGALS7 LGALS7B PPIB PRAP1 RPA1 TERF1	117 interacting genes: ABI2 ACOT7 ADAMTSL4 ALG13 APOBEC1 ARID5A ATAD2 ATP23 BAP1 BCAS3 BCL2 BCL6B BEX1 BLZF1 C3orf38 CASP2 CASZ1 CBFA2T2 CCL5 DDIT4L DIRAS3 DZIP3 EFEMP1 EPSTI1 ERRFI1 FAM214B FAM222B FARS2 FTH1 FYN GLCE GPANK1 GPS2 GRAP2 HOXA1 HSPA1A HSPA1B HSPA1L HSPA2 HSPA6 HSPA8 IL13RA2 IL24 IST1 ITIH5 KCTD6 KCTD7 KIF5B KLK5 KLK7 KLK9 KRTAP13-1 KRTAP13-4 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP6-3 LASP1 LRATD2 LYPD3 MAGED1 MEI4 MRC2 MTA3 MYOZ1 MYOZ3 MYPOP NAT2 ODF1 ODF3L1 P4HA3 PDCD6 PDLIM2 PEF1 PGRMC2 PHF19 PLAC8 PPIL6 PPP1R32 PRDM14 PSMB5 PYCR3 RAMAC RASL10B RHOBTB2 RNF20 RPL22 RUNX1 SAMD4A SAXO1 SCGB3A1 SH3RF2 SIAH1 SNRPB SNRPC SS18L1 SUOX TBC1D3B TBC1D3G TBC1D7 TCL1B TEKT5 TFAP2D THRSP TINAGL1 TLE5 TNFRSF1A TNFRSF25 TRAPPC6A TSG101 UNKL USP22 VPS37C ZBTB45 ZBTB5 ZIM2
Entrez ID		3310	9530
HPRD ID		00775	04861
Ensembl ID		ENSG00000173110	ENSG00000156735
Uniprot IDs		A0A384NKX5 B3KSM6 P17066	O95429
PDB IDs		3FE1	1M62 1M7K
Enriched GO Terms of Interacting Partners?
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