HSPA6 and CISH

Data Source:
BioGRID (two hybrid)

		HSPA6	CISH
Description		heat shock protein family A (Hsp70) member 6	cytokine inducible SH2 containing protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane COP9 Signalosome Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Cellular_component Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex
	Molecular Function	Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding	Molecular_function Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Response To Unfolded Protein Vesicle-mediated Transport Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Neutrophil Degranulation Chaperone Cofactor-dependent Protein Refolding Cellular Heat Acclimation	Regulation Of Cell Growth Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Intracellular Signal Transduction Interleukin-7-mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Phosphatidylinositol Phosphorylation
Pathways		Regulation of HSF1-mediated heat shock response Neutrophil degranulation	Interleukin-7 signaling Neddylation Growth hormone receptor signaling
Drugs
Diseases
GWAS		Birth weight ( 31043758) Blood protein levels ( 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 28067908 23128233) Offspring birth weight ( 31043758) Ulcerative colitis ( 28067908 21297633)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		16 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FLNA KRT222 LGALS7 LGALS7B PPIB PRAP1 RPA1 TERF1	17 interacting genes: CSF2RB CSF3R EPOR ERBB2 ETV5 GHR HSPA6 IL2RB IL3RA KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2
Entrez ID		3310	1154
HPRD ID		00775	03897
Ensembl ID		ENSG00000173110	ENSG00000114737
Uniprot IDs		A0A384NKX5 B3KSM6 P17066	Q9NSE2
PDB IDs		3FE1
Enriched GO Terms of Interacting Partners?
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