HSPA6 and COMMD6

Data Source:
BioGRID (two hybrid)

		HSPA6	COMMD6
Description		heat shock protein family A (Hsp70) member 6	COMM domain containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane COP9 Signalosome Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm
	Molecular Function	Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding	Protein Binding NF-kappaB Binding
	Biological Process	Response To Unfolded Protein Vesicle-mediated Transport Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Neutrophil Degranulation Chaperone Cofactor-dependent Protein Refolding Cellular Heat Acclimation	Negative Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Regulation of HSF1-mediated heat shock response Neutrophil degranulation	Neddylation
Drugs
Diseases
GWAS		Birth weight ( 31043758) Blood protein levels ( 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 28067908 23128233) Offspring birth weight ( 31043758) Ulcerative colitis ( 28067908 21297633)	Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483) Red blood cell count ( 29403010)
Interacting Genes		16 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FLNA KRT222 LGALS7 LGALS7B PPIB PRAP1 RPA1 TERF1	3 interacting genes: COMMD1 COMMD9 HSPA6
Entrez ID		3310	170622
HPRD ID		00775	13084
Ensembl ID		ENSG00000173110	ENSG00000188243
Uniprot IDs		A0A384NKX5 B3KSM6 P17066	Q7Z4G1
PDB IDs		3FE1
Enriched GO Terms of Interacting Partners?
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