RGS16 and GNAQ

Data Source:
HPRD (in vitro)

		RGS16	GNAQ
Description		regulator of G protein signaling 16	G protein subunit alpha q
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Intrinsic Component Of Membrane	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Synapse Extracellular Exosome
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding Calmodulin Binding	G Protein-coupled Receptor Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Visual Perception Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity	Action Potential Negative Regulation Of Protein Kinase Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Blood Coagulation Phototransduction, Visible Light Entrainment Of Circadian Clock Platelet Activation Positive Regulation Of GTPase Activity Protein Stabilization Regulation Of Canonical Wnt Signaling Pathway
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events	Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)
Drugs
Diseases
GWAS		Chronotype ( 26955885 30696823 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 26835600 27494321) Sleep traits (multi-trait analysis) ( 27992416)	Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		14 interacting genes: CREB3L2 CSK EGFR GDE1 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAT1 LYN SRC ST14	48 interacting genes: ADHFE1 ADRA1B AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRK2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		6004	2776
HPRD ID		03945	02998
Ensembl ID		ENSG00000143333	ENSG00000156052
Uniprot IDs		O15492	A0A024R240 P50148
PDB IDs		2BT2 2IK8	6VU5
Enriched GO Terms of Interacting Partners?
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