GNAQ and TUB

Data Source:
HPRD (in vitro)

		GNAQ	TUB
Description		G protein subunit alpha q	TUB bipartite transcription factor
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Synapse Extracellular Exosome	Extracellular Region Nucleus Cytoplasm Cytosol Plasma Membrane Cilium
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding	G Protein-coupled Receptor Binding Protein-containing Complex Binding Intraciliary Transport Particle A Binding
	Biological Process	Action Potential Negative Regulation Of Protein Kinase Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Blood Coagulation Phototransduction, Visible Light Entrainment Of Circadian Clock Platelet Activation Positive Regulation Of GTPase Activity Protein Stabilization Regulation Of Canonical Wnt Signaling Pathway	Phagocytosis, Recognition Sensory Perception Of Sound Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Hormone Intraciliary Transport Photoreceptor Cell Maintenance Positive Regulation Of Phagocytosis Retina Development In Camera-type Eye Protein Localization To Cilium Receptor Localization To Non-motile Cilium Protein Localization To Photoreceptor Outer Segment
Pathways		Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)
Drugs			(1R,2R,3S,4R,6S)-3,4,6-Trihydroxy-5-{[(S)-hydroxy(3-hydroxy-2-oxopropoxy)phosphoryl]oxy}-1,2-cyclohexanediyl bis[dihydrogen (phosphate)]
Diseases
GWAS		Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Body mass index ( 26426971 20935630) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Coronary artery disease in type 1 diabetes ( 29695241) Familial lung adenocarcinoma ( 29924316) Familial lung cancer ( 29924316) Malaria ( 31844061)
Interacting Genes		48 interacting genes: ADHFE1 ADRA1B AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRK2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1	9 interacting genes: ABL1 GNAQ GRB2 IRS1 JAK2 LCK PIK3R1 PLCG1 SRC
Entrez ID		2776	7275
HPRD ID		02998	03121
Ensembl ID		ENSG00000156052	ENSG00000166402
Uniprot IDs		A0A024R240 P50148	P50607
PDB IDs		6VU5	1S31
Enriched GO Terms of Interacting Partners?
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