GNAQ and HTR6

Data Source:
HPRD (in vivo)

		GNAQ	HTR6
Description		G protein subunit alpha q	5-hydroxytryptamine receptor 6
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Synapse Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendrite Synapse
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity
	Biological Process	Action Potential Negative Regulation Of Protein Kinase Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Blood Coagulation Phototransduction, Visible Light Entrainment Of Circadian Clock Platelet Activation Positive Regulation Of GTPase Activity Protein Stabilization Regulation Of Canonical Wnt Signaling Pathway	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Cerebral Cortex Cell Migration Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)	Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)
Interacting Genes		48 interacting genes: ADHFE1 ADRA1B AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRK2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1	31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1
Entrez ID		2776	3362
HPRD ID		02998	03066
Ensembl ID		ENSG00000156052	ENSG00000158748
Uniprot IDs		A0A024R240 P50148	P50406
PDB IDs		6VU5
Enriched GO Terms of Interacting Partners?
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