GNAQ and RGS18

Data Source:
HPRD (in vitro)

		GNAQ	RGS18
Description		G protein subunit alpha q	regulator of G protein signaling 18
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Synapse Extracellular Exosome	Cytoplasm Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding	GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	Action Potential Negative Regulation Of Protein Kinase Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Blood Coagulation Phototransduction, Visible Light Entrainment Of Circadian Clock Platelet Activation Positive Regulation Of GTPase Activity Protein Stabilization Regulation Of Canonical Wnt Signaling Pathway	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Food addiction ( 27106561) Refractive error ( 32231278)
Interacting Genes		48 interacting genes: ADHFE1 ADRA1B AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRK2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1	6 interacting genes: APP GNAI1 GNAI2 GNAI3 GNAQ LMNA
Entrez ID		2776	64407
HPRD ID		02998	06224
Ensembl ID		ENSG00000156052	ENSG00000150681
Uniprot IDs		A0A024R240 P50148	Q9NS28
PDB IDs		6VU5	2DLV 2JM5 2OWI
Enriched GO Terms of Interacting Partners?
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