RELB and USP11

Data Source:
HPRD (in vitro)

		RELB	USP11
Description		RELB proto-oncogene, NF-kB subunit	ubiquitin specific peptidase 11
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Centrosome Cytosol Transcription Repressor Complex Protein-containing Complex	Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Kinase Binding Identical Protein Binding	RNA Polymerase II Transcription Corepressor Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Gene Expression Antigen Processing And Presentation Lymphocyte Differentiation Negative Regulation Of Interferon-beta Production Circadian Regulation Of Gene Expression Cellular Response To Stress Response To Cytokine NIK/NF-kappaB Signaling Myeloid Dendritic Cell Differentiation T-helper 1 Cell Differentiation Innate Immune Response Negative Regulation Of Transcription, DNA-templated Cellular Response To Osmotic Stress	Ubiquitin-dependent Protein Catabolic Process Viral Process Protein Deubiquitination Protein Phosphopantetheinylation
Pathways		Dectin-1 mediated noncanonical NF-kB signaling CD209 (DC-SIGN) signaling NIK-->noncanonical NF-kB signaling	Association of TriC/CCT with target proteins during biosynthesis Ub-specific processing proteases
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Red cell distribution width ( 32888494) Triglyceride levels ( 32154731)
Interacting Genes		25 interacting genes: BCL7A BUD31 CDK1 CTSL DPF2 EHMT2 EZH2 GSK3B HDAC6 KPNA2 KPNA6 MALT1 MT1M MTAP NFKB1 NFKB2 RELA SIN3A SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCE1 UQCRFS1 USP11	21 interacting genes: BMI1 BRCA2 CBX8 CDKN1A DECR2 EIF4B LIMS1 LLGL1 MBD3 MTA2 PCGF2 PML RANBP9 RELB RNF2 RPS6KB1 SETDB1 SUMO2 TBL3 TP53 UBC
Entrez ID		5971	8237
HPRD ID		06886	02081
Ensembl ID		ENSG00000104856	ENSG00000102226
Uniprot IDs		D6R992 Q01201	B4DGK3 P51784
PDB IDs			4MEL 5OK6
Enriched GO Terms of Interacting Partners?
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