USP11 and MTA2

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, imaging technique)

		USP11	MTA2
Description		ubiquitin specific peptidase 11	metastasis associated 1 family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol	Histone Deacetylase Complex Chromatin Nucleoplasm Transcription Regulator Complex Membrane NuRD Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Transcription Corepressor Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding	RNA Polymerase II Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Activity Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Viral Process Protein Deubiquitination Protein Phosphopantetheinylation	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Assembly Or Disassembly Regulation Of Fibroblast Migration Histone Deacetylation ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Association of TriC/CCT with target proteins during biosynthesis Ub-specific processing proteases	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS			Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		21 interacting genes: BMI1 BRCA2 CBX8 CDKN1A DECR2 EIF4B LIMS1 LLGL1 MBD3 MTA2 PCGF2 PML RANBP9 RELB RNF2 RPS6KB1 SETDB1 SUMO2 TBL3 TP53 UBC	23 interacting genes: APPL1 APPL2 BCL11B ERCC6 ESR1 FKBP3 H3-4 HNRNPD MBD3 MBD3L2 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN SUMO2 TP53 TSC22D3 UBE3C USP11 YY1
Entrez ID		8237	9219
HPRD ID		02081	07233
Ensembl ID		ENSG00000102226	ENSG00000149480
Uniprot IDs		B4DGK3 P51784	A0A024R534 O94776
PDB IDs		4MEL 5OK6
Enriched GO Terms of Interacting Partners?
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