USP11 and EIF4B

Data Source:
BioGRID (enzymatic study)

		USP11	EIF4B
Description		ubiquitin specific peptidase 11	eukaryotic translation initiation factor 4B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol	Cytosol Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	RNA Polymerase II Transcription Corepressor Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding	RNA Binding Translation Initiation Factor Activity Protein Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Viral Process Protein Deubiquitination Protein Phosphopantetheinylation	Formation Of Translation Preinitiation Complex Translational Initiation Regulation Of Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex Assembly
Pathways		Association of TriC/CCT with target proteins during biosynthesis Ub-specific processing proteases	L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Prostate cancer ( 21743057)
Interacting Genes		21 interacting genes: BMI1 BRCA2 CBX8 CDKN1A DECR2 EIF4B LIMS1 LLGL1 MBD3 MTA2 PCGF2 PML RANBP9 RELB RNF2 RPS6KB1 SETDB1 SUMO2 TBL3 TP53 UBC	18 interacting genes: ACD CASP3 CSNK2A1 EIF3A EIF4E LAMTOR5 LINC01554 PABPC1 PAK2 POT1 RHOU RPS6KB1 SFN SMAD3 SRPK2 TERF1 TINF2 USP11
Entrez ID		8237	1975
HPRD ID		02081	04892
Ensembl ID		ENSG00000102226	ENSG00000063046
Uniprot IDs		B4DGK3 P51784	B4DRM3 E7EX17 P23588 Q7Z5Y0
PDB IDs		4MEL 5OK6	1WI8 2J76 6FEC
Enriched GO Terms of Interacting Partners?
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