RELB and SMARCE1

Data Source:
HPRD (in vitro)

		RELB	SMARCE1
Description		RELB proto-oncogene, NF-kB subunit	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Centrosome Cytosol Transcription Repressor Complex Protein-containing Complex	Nuclear Chromosome Chromatin Nucleus Nucleoplasm SWI/SNF Complex Protein-containing Complex NpBAF Complex NBAF Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Kinase Binding Identical Protein Binding	Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Binding N-acetyltransferase Activity Nuclear Receptor Binding Nucleosomal DNA Binding Protein N-terminus Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Gene Expression Antigen Processing And Presentation Lymphocyte Differentiation Negative Regulation Of Interferon-beta Production Circadian Regulation Of Gene Expression Cellular Response To Stress Response To Cytokine NIK/NF-kappaB Signaling Myeloid Dendritic Cell Differentiation T-helper 1 Cell Differentiation Innate Immune Response Negative Regulation Of Transcription, DNA-templated Cellular Response To Osmotic Stress	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Neurogenesis ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated
Pathways		Dectin-1 mediated noncanonical NF-kB signaling CD209 (DC-SIGN) signaling NIK-->noncanonical NF-kB signaling	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Red cell distribution width ( 32888494) Triglyceride levels ( 32154731)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 31959851 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Eczema ( 31361310)
Interacting Genes		25 interacting genes: BCL7A BUD31 CDK1 CTSL DPF2 EHMT2 EZH2 GSK3B HDAC6 KPNA2 KPNA6 MALT1 MT1M MTAP NFKB1 NFKB2 RELA SIN3A SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCE1 UQCRFS1 USP11	89 interacting genes: AMOTL2 AR ARID2 BAZ1B BRAP BRMS1 CCDC136 CCDC172 CCDC183 CCHCR1 CDR2 CEP170P1 CEP63 CEP70 CYSRT1 DISC1 EPS8 ESR1 ESR2 EXOC4 EXOC7 FAM217B FSD2 GATA1 GOLGA2 GOLGA6L9 GRIPAP1 IFT74 IFT88 ING5 ITCH JAKMIP2 KIFC3 KLF1 KRT14 KRT15 KRT16 KRT19 KRT27 KRT31 KRT34 KRT35 KRT37 KRT39 KRT40 KRTAP1-1 KRTAP10-8 KRTAP10-9 KRTAP6-3 MDM2 MED4 MEOX2 MIPOL1 MRFAP1L1 MTUS2 NBPF22P NCOA1 NCOA2 NCOA3 NOTCH2NLA NR0B2 NR3C1 NUP62 OIP5 PGR PRMT5 PSMC6 RALBP1 RARB RCOR1 RELB RINT1 SIN3A SIN3B SMAD1 SMARCA4 SPAG5 SRC STX11 SYCE1 TEX12 TFE3 TFIP11 TNIK TRIM54 TRIP10 TXLNA USHBP1 VPS52
Entrez ID		5971	6605
HPRD ID		06886	04382
Ensembl ID		ENSG00000104856	ENSG00000073584
Uniprot IDs		D6R992 Q01201	A0A024R1S7 Q969G3
PDB IDs			6LTH 6LTJ 7CYU
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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