MCOLN1 and SEC22A

Data Source:
BioGRID (two hybrid)

		MCOLN1	SEC22A
Description		mucolipin TRP cation channel 1	SEC22 homolog A, vesicle trafficking protein
Image			No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Nucleoplasm Lysosome Lysosomal Membrane Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Late Endosome Membrane Cell Projection Intracellular Membrane-bounded Organelle Receptor Complex	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Cation Channel Activity Iron Ion Transmembrane Transporter Activity Protein Binding Lipid Binding NAADP-sensitive Calcium-release Channel Activity Intracellular Phosphatidylinositol-3,5-bisphosphate-sensitive Cation Channel Activity Ligand-gated Calcium Channel Activity	Transporter Activity Protein Binding
	Biological Process	Adaptive Immune Response Cation Transport Calcium-mediated Signaling Transferrin Transport Iron Ion Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To PH Phagosome Maturation Autophagosome Maturation	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport
Pathways		TRP channels Transferrin endocytosis and recycling	COPII-mediated vesicle transport
Drugs
Diseases		Mucolipidosis IV
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean platelet volume ( 32888494) Opioid overdose severity score ( 31362332)	Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		5 interacting genes: APPBP2 GPR35 SEC22A SLC35E1 TRIM27	106 interacting genes: ADGRG3 AQP6 ASGR2 ATP6AP2 BIK BNIP3 C10orf67 C16orf54 C16orf92 CALN1 CD207 CD300A CD7 CD74 CISD2 CLEC10A CLEC12B CLEC2D CLEC7A CREB3L1 CYB561 CYBRD1 DDIT4L DIABLO DTX2 EDA ELOVL4 ERLIN1 ERVFRD-1 FAM174A FAM209A FATE1 FUT3 GAD2 GGT6 GJB5 GJB6 GPR37L1 GRAMD2B HAVCR2 HCST HSD17B11 ICAM3 KCNJ2 LDLRAD1 LHFPL5 LMNA LPAR6 LRRC25 LSMEM2 MCOLN1 MFF MGST2 MINAR1 MS4A14 MS4A3 MS4A4A MSR1 OPRM1 PACC1 PEX12 PHB PTGES RASGRP4 RETREG3 RILPL1 RNASEK RNF144A RNF19B RNF5 SAR1A SCN3B SDHAF2 SFTPC SLC14A2 SLC30A2 SLC35C2 SLC39A2 SMIM3 SPAG4 STMN4 STOML3 STX1A STX2 STX4 SUSD3 SYNE4 TFR2 TLCD4 TMED9 TMEM106C TMEM159 TMEM174 TMEM237 TMEM45B TMEM52B TMEM71 TMEM79 TMIE TMPRSS2 TNFSF14 TP53INP1 TRAT1 TRIM59 TYRP1 ZFYVE27
Entrez ID		57192	26984
HPRD ID		05582	15313
Ensembl ID		ENSG00000090674	ENSG00000121542
Uniprot IDs		Q9GZU1	Q96IW7
PDB IDs		5TJA 5TJB 5TJC 5WJ5 5WJ9 6E7P 6E7Y 6E7Z
Enriched GO Terms of Interacting Partners?
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