DMAP1 and TLK2

Data Source:
BioGRID (two hybrid)

		DMAP1	TLK2
Description		DNA methyltransferase 1 associated protein 1	tousled like kinase 2
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GO Annotations	Cellular Component	Swr1 Complex Nucleus Nucleoplasm Replication Fork Cytoplasm Cytosol NuA4 Histone Acetyltransferase Complex	Nucleus Intermediate Filament Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Transcription Corepressor Activity Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair DNA Methylation Regulation Of Growth Positive Regulation Of Protein Import Into Nucleus Histone Exchange Histone H4 Acetylation Histone H2A Acetylation Response To Ethanol Negative Regulation Of Transcription, DNA-templated	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Negative Regulation Of Autophagy Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Cellular Response To Gamma Radiation
Pathways		HATs acetylate histones
Drugs			Fostamatinib
Diseases
GWAS		Metabolite levels ( 23823483)	Heel bone mineral density ( 30598549) Lifespan ( 25918517)
Interacting Genes		38 interacting genes: ARFIP2 BFSP2 C1orf216 CCHCR1 CDCA7L DAXX DNMT1 EXOC8 GAS8 GINS4 HDAC2 HSF2BP HSPB1 ING1 KRT75 LMNB1 LRSAM1 MIS18A MNAT1 MORF4L1 MRGBP NAP1L2 PFDN1 PIBF1 RGS6 SAAL1 SBK3 SUOX TCEANC TCHP TLK2 TOMM34 TRIM21 TSG101 TSGA10IP TXLNA TXLNB URI1	17 interacting genes: ASF1A ASF1B AURKA CEP70 DMAP1 FEZ1 FEZ2 FRMD6 GMCL1 IRF4 IRF7 MBP PAX5 PAX6 TLK1 UBE2I YWHAZ
Entrez ID		55929	11011
HPRD ID		05465	10527
Ensembl ID		ENSG00000178028	ENSG00000146872
Uniprot IDs		Q9NPF5	B4DUC2 J3QLK5 Q86UE8
PDB IDs		3HM5 4IEJ	5O0Y
Enriched GO Terms of Interacting Partners?
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