TLK2 and ASF1A

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		TLK2	ASF1A
Description		tousled like kinase 2	anti-silencing function 1A histone chaperone
Image
GO Annotations	Cellular Component	Nucleus Intermediate Filament Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Protein-containing Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Chromatin Binding Protein Binding Histone Binding
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Negative Regulation Of Autophagy Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Cellular Response To Gamma Radiation	Osteoblast Differentiation DNA Repair Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Negative Regulation Of Chromatin Silencing Muscle Cell Differentiation
Pathways			Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs		Fostamatinib
Diseases
GWAS		Heel bone mineral density ( 30598549) Lifespan ( 25918517)	Mean platelet volume ( 32888494) Multiple sclerosis ( 31604244) QT interval ( 19305408)
Interacting Genes		17 interacting genes: ASF1A ASF1B AURKA CEP70 DMAP1 FEZ1 FEZ2 FRMD6 GMCL1 IRF4 IRF7 MBP PAX5 PAX6 TLK1 UBE2I YWHAZ	35 interacting genes: ASF1B CDAN1 CHAF1A CHAF1B CHEK2 H3-3A H3-4 H3C3 H3C6 H4-16 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HIRA HTATIP2 MCM2 NASP PAFAH1B2 PRR3 ST13 TAF1 TLK1 TLK2 VPS28 ZDHHC17
Entrez ID		11011	25842
HPRD ID		10527	16459
Ensembl ID		ENSG00000146872	ENSG00000111875
Uniprot IDs		B4DUC2 J3QLK5 Q86UE8	Q9Y294
PDB IDs		5O0Y	1TEY 2I32 2IIJ 2IO5 3AAD 5C3I 6F0F 6F0G 6F0H
Enriched GO Terms of Interacting Partners?
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