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TLK2 and MBP
Data Source:
HPRD
(in vitro)
TLK2
MBP
Description
tousled like kinase 2
myelin basic protein
Image
GO Annotations
Cellular Component
Nucleus
Intermediate Filament
Perinuclear Region Of Cytoplasm
Nucleus
Plasma Membrane
Cell Surface
Protein-containing Complex
Internode Region Of Axon
Neuronal Cell Body
Myelin Sheath
Compact Myelin
Synapse
Cell Periphery
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Identical Protein Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protease Binding
Protein Binding
Calmodulin Binding
Structural Constituent Of Myelin Sheath
Biological Process
Regulation Of Chromatin Assembly Or Disassembly
Chromatin Organization
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
Cell Cycle
Chromosome Segregation
Negative Regulation Of Autophagy
Peptidyl-serine Phosphorylation
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Intracellular Signal Transduction
Cellular Response To Gamma Radiation
MAPK Cascade
Immune Response
Chemical Synaptic Transmission
Central Nervous System Development
Sensory Perception Of Sound
Axon Ensheathment
Response To Toxic Substance
Substantia Nigra Development
Positive Regulation Of Interleukin-6 Production
Negative Regulation Of Heterotypic Cell-cell Adhesion
Maintenance Of Blood-brain Barrier
Myelination
Membrane Organization
Positive Regulation Of Metalloendopeptidase Activity
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Fostamatinib
Diseases
GWAS
Heel bone mineral density (
30598549
)
Lifespan (
25918517
)
Age-related macular degeneration (geographic atrophy) (
22705344
)
Blood osmolality (transformed sodium) (
28360221
)
Depression in smokers (
30219690
)
Erythrocyte cadmium concentration in never smokers (
27005419
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Verbal declarative memory (
25648963
)
Interacting Genes
17 interacting genes:
ASF1A
ASF1B
AURKA
CEP70
DMAP1
FEZ1
FEZ2
FRMD6
GMCL1
IRF4
IRF7
MBP
PAX5
PAX6
TLK1
UBE2I
YWHAZ
81 interacting genes:
ABL1
ADRB2
APTX
ATN1
ATXN1
AURKA
BMP2K
CCR1
CDK1
CDK12
CDK5
CDK7
CDK8
CDK9
CLK1
CTDSP1
CTDSPL
DYRK1B
HIPK2
HLA-DRA
IKBKE
ILK
IRAK1
IRAK4
LIMK1
LIMK2
LRRK2
MAG
MAP2K1
MAP3K1
MAP3K3
MAP3K5
MAPK1
MAPK11
MAPK12
MAPK13
MAPK14
MAPK15
MAPK3
MAPK8
MAPKAPK5
MELK
MICU2
MKNK1
MMP7
NEK9
PAK1
PDGFRL
PKN1
PLEKHF2
PLP1
PPP2R5C
PRKACA
PRKCA
PRKCB
PRKCD
PRKCI
PRKCZ
PRKDC
PRMT1
PRMT5
PTAFR
PTPRA
RAF1
RAN
RPS6KA5
RTN4
SQSTM1
SRPK1
STK16
STK26
STK3
STK39
STK4
TBK1
TLK1
TLK2
TRAF6
TRPM7
TSSK6
ULK1
Entrez ID
11011
4155
HPRD ID
10527
01158
Ensembl ID
ENSG00000146872
ENSG00000197971
Uniprot IDs
B4DUC2
J3QLK5
Q86UE8
A0A024R384
P02686
PDB IDs
5O0Y
1BX2
1FV1
1HQR
1K2D
1QCL
1YMM
1ZGL
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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