FERMT1 and ILK

Data Source:
BioGRID (pull down)

		FERMT1	ILK
Description		FERM domain containing kindlin 1	integrin linked kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Junction Cell-substrate Junction Ruffle Membrane Cell Periphery	Stress Fiber Nucleoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Sarcomere Lamellipodium
	Molecular Function	Integrin Binding Actin Filament Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Integrin Activation Positive Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Protein Import Into Nucleus Keratinocyte Proliferation Keratinocyte Migration Negative Regulation Of Timing Of Anagen Positive Regulation Of Transforming Growth Factor Beta Production Basement Membrane Organization Negative Regulation Of Canonical Wnt Signaling Pathway Establishment Of Epithelial Cell Polarity Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Stem Cell Proliferation	Cell Morphogenesis Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Platelet Aggregation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling
Pathways			Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
Drugs
Diseases		Kindler syndrome
GWAS		Abdominal aortic aneurysm ( 27899403) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lung function (low FEV1 vs high FEV1) ( 26423011) Retinal detachment or retinal break ( 31816047) Smooth-surface caries ( 24556642) Triglyceride levels x loop diuretics use interaction ( 31806883)	Malaria ( 31844061)
Interacting Genes		4 interacting genes: ILK ITGB1 PARVA SRPK1	42 interacting genes: AKT1 CASP8 CASP9 CAV1 CKB FERMT1 FERMT2 FERMT3 GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MATK MBP MIPEP NCK2 NOTCH1 PARVA PARVB PARVG PDPK1 PPP1R12A PTPN11 PXN RICTOR RNF19A RPL13 SERPINA4 SHC1 SNRNP35 SUMO2 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746
Entrez ID		55612	3611
HPRD ID		06388	03842
Ensembl ID		ENSG00000101311	ENSG00000166333
Uniprot IDs		Q49AC8 Q54A15 Q9BQL6	Q13418 V9HWF0
PDB IDs			2KBX 3F6Q 3IXE 3KMU 3KMW 3REP 4HI8 4HI9 6MIB
Enriched GO Terms of Interacting Partners?
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