ILK and PARVB

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ILK	PARVB
Description		integrin linked kinase	parvin beta
Image
GO Annotations	Cellular Component	Stress Fiber Nucleoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Sarcomere Lamellipodium	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Actin Binding Protein Binding
	Biological Process	Cell Morphogenesis Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Platelet Aggregation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling	Establishment Or Maintenance Of Cell Polarity Cell Projection Assembly Lamellipodium Assembly Actin Cytoskeleton Reorganization Substrate Adhesion-dependent Cell Spreading Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape
Pathways		Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions	Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs
Diseases
GWAS		Malaria ( 31844061)	Alzheimer's disease (cognitive decline) ( 23535033) Hematological and biochemical traits ( 20139978) Lewy body disease ( 25188341) Nonalcoholic fatty liver disease ( 22719876) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Response to chemotherapy in breast cancer (hypertension) (bevacizumab) ( 25117820) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Systemic sclerosis (anti-centromere-positive) ( 29293537)
Interacting Genes		42 interacting genes: AKT1 CASP8 CASP9 CAV1 CKB FERMT1 FERMT2 FERMT3 GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MATK MBP MIPEP NCK2 NOTCH1 PARVA PARVB PARVG PDPK1 PPP1R12A PTPN11 PXN RICTOR RNF19A RPL13 SERPINA4 SHC1 SNRNP35 SUMO2 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746	2 interacting genes: ARHGEF6 ILK
Entrez ID		3611	29780
HPRD ID		03842	16284
Ensembl ID		ENSG00000166333	ENSG00000188677
Uniprot IDs		Q13418 V9HWF0	A0A087WZB5 Q9HBI1
PDB IDs		2KBX 3F6Q 3IXE 3KMU 3KMW 3REP 4HI8 4HI9 6MIB	4EDL 4EDM 4EDN
Enriched GO Terms of Interacting Partners?
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