ILK and FERMT2

Data Source:
BioGRID (biochemical, pull down, pull down, affinity chromatography technology)

		ILK	FERMT2
Description		integrin linked kinase	FERM domain containing kindlin 2
Image
GO Annotations	Cellular Component	Stress Fiber Nucleoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Sarcomere Lamellipodium	Stress Fiber Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Adherens Junction Focal Adhesion Cell Cortex Cell Surface Cell Junction Cell-substrate Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Lamellipodium Membrane I Band
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Actin Binding Integrin Binding Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Type I Transforming Growth Factor Beta Receptor Binding SMAD Binding Actin Filament Binding
	Biological Process	Cell Morphogenesis Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Platelet Aggregation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling	Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Integrin Activation Positive Regulation Of Integrin Activation Cell Junction Assembly Adherens Junction Maintenance Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Myosin Light Chain Kinase Activity Negative Regulation Of Vascular Permeability Positive Regulation Of GTPase Activity Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Focal Adhesion Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Limb Development Negative Regulation Of Cell Death Positive Regulation Of ERK1 And ERK2 Cascade Protein Localization To Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Nucleus Protein Localization To Cell Junction Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells
Pathways		Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions	Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Malaria ( 31844061)	Alzheimer's disease (late onset) ( 24162737) Diastolic blood pressure ( 27841878) Glaucoma (primary angle closure) ( 27064256) Intraocular pressure ( 29617998 29785010 31959993 30054594) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 30046033 32439900) Prostate cancer ( 23535732) Pulse pressure ( 27841878) Systolic blood pressure ( 28135244 27841878)
Interacting Genes		42 interacting genes: AKT1 CASP8 CASP9 CAV1 CKB FERMT1 FERMT2 FERMT3 GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MATK MBP MIPEP NCK2 NOTCH1 PARVA PARVB PARVG PDPK1 PPP1R12A PTPN11 PXN RICTOR RNF19A RPL13 SERPINA4 SHC1 SNRNP35 SUMO2 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746	8 interacting genes: APP CMTM5 FBLIM1 ILK ITGB1 LIMS1 PARVA TRIM15
Entrez ID		3611	10979
HPRD ID		03842	06374
Ensembl ID		ENSG00000166333	ENSG00000073712
Uniprot IDs		Q13418 V9HWF0	A0A024R687 Q96AC1
PDB IDs		2KBX 3F6Q 3IXE 3KMU 3KMW 3REP 4HI8 4HI9 6MIB	2LGX 2LKO 2MSU 4F7H 6U4N 6XTJ
Enriched GO Terms of Interacting Partners?
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