ILK and MATK

Data Source:
BioGRID (pull down)

		ILK	MATK
Description		integrin linked kinase	megakaryocyte-associated tyrosine kinase
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GO Annotations	Cellular Component	Stress Fiber Nucleoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Sarcomere Lamellipodium	Cytosol Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Cell Morphogenesis Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Platelet Aggregation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling	Protein Phosphorylation Positive Regulation Of Cell Population Proliferation Peptidyl-tyrosine Phosphorylation ERBB2 Signaling Pathway
Pathways		Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions	Downregulation of ERBB2 signaling
Drugs			Fostamatinib
Diseases
GWAS		Malaria ( 31844061)	Obesity-related traits ( 23251661)
Interacting Genes		42 interacting genes: AKT1 CASP8 CASP9 CAV1 CKB FERMT1 FERMT2 FERMT3 GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MATK MBP MIPEP NCK2 NOTCH1 PARVA PARVB PARVG PDPK1 PPP1R12A PTPN11 PXN RICTOR RNF19A RPL13 SERPINA4 SHC1 SNRNP35 SUMO2 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746	24 interacting genes: AKT1 AR CACNA1A CD36 ERBB2 ERBB3 ERBB4 EWSR1 FRS3 HSPA5 HSPA9 ILK KIT LRRK1 LRRK2 LYN MET NTRK1 PTK2B PTPRD PXN SIRPA SMURF1 SRC
Entrez ID		3611	4145
HPRD ID		03842	02496
Ensembl ID		ENSG00000166333	ENSG00000007264
Uniprot IDs		Q13418 V9HWF0	F1T0G6 P42679
PDB IDs		2KBX 3F6Q 3IXE 3KMU 3KMW 3REP 4HI8 4HI9 6MIB	1JWO 1X6G 3US4
Enriched GO Terms of Interacting Partners?
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