FERMT1 and PARVA

Data Source:
BioGRID (pull down)

		FERMT1	PARVA
Description		FERM domain containing kindlin 1	parvin alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Junction Cell-substrate Junction Ruffle Membrane Cell Periphery	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium
	Molecular Function	Integrin Binding Actin Filament Binding	Actin Binding Protein Kinase Inhibitor Activity Protein Binding Cadherin Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Integrin Activation Positive Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Protein Import Into Nucleus Keratinocyte Proliferation Keratinocyte Migration Negative Regulation Of Timing Of Anagen Positive Regulation Of Transforming Growth Factor Beta Production Basement Membrane Organization Negative Regulation Of Canonical Wnt Signaling Pathway Establishment Of Epithelial Cell Polarity Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Stem Cell Proliferation	Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Negative Regulation Of Protein Kinase Activity Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Shape Cell Projection Assembly Actin Cytoskeleton Reorganization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Protein Stabilization Cilium Assembly Actin-mediated Cell Contraction Smooth Muscle Cell Chemotaxis
Pathways			Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs
Diseases		Kindler syndrome
GWAS		Abdominal aortic aneurysm ( 27899403) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lung function (low FEV1 vs high FEV1) ( 26423011) Retinal detachment or retinal break ( 31816047) Smooth-surface caries ( 24556642) Triglyceride levels x loop diuretics use interaction ( 31806883)	Depressive symptoms (SSRI exposure interaction) ( 25649181) Diisocyanate-induced asthma ( 25918132) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HOMA-B (corrected for HOMA-IR) ( 30369944) Lung adenocarcinoma ( 28604730) Mortality in heart failure ( 20400778)
Interacting Genes		4 interacting genes: ILK ITGB1 PARVA SRPK1	14 interacting genes: ACTA1 APP FERMT1 FERMT2 FERMT3 HSPB2 ILK LIMS1 MAP2K1 MLH1 NFE2L1 PXN UBE3A UBQLN1
Entrez ID		55612	55742
HPRD ID		06388	16283
Ensembl ID		ENSG00000101311	ENSG00000197702
Uniprot IDs		Q49AC8 Q54A15 Q9BQL6	Q9NVD7
PDB IDs			2K2R 2VZC 2VZD 2VZG 2VZI 3KMU 3KMW 3REP 6MIB
Enriched GO Terms of Interacting Partners?
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