DCUN1D1 and ABRAXAS2

Data Source:
BioGRID (two hybrid)

		DCUN1D1	ABRAXAS2
Description		defective in cullin neddylation 1 domain containing 1	abraxas 2, BRISC complex subunit
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Centrosome Cytosol Midbody Spindle Pole Centrosome Microtubule Minus-end BRISC Complex
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Protein Binding Microtubule Binding Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Regulation Of Protein Ubiquitination Post-translational Protein Modification Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation	Mitotic Cell Cycle Response To Ischemia Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Protein Deubiquitination Cell Division Protein K63-linked Deubiquitination Mitotic Spindle Assembly
Pathways		Neddylation	Metalloprotease DUBs
Drugs
Diseases
GWAS		Parkinson's disease ( 27182965 28011712) Subjective response to lithium treatment ( 26503763)	Bone mineral content ( 31790847)
Interacting Genes		33 interacting genes: ABRAXAS2 ARIH1 ARIH2 ARRDC3 AURKB CALM1 CAND1 CDIP1 CUL5 DAZAP2 DVL2 FAM168A GMPPA LAPTM5 LZTS2 MAP3K1 NEDD4 PLEKHB2 RHOA RNF11 SMAD2 SUSD6 TLE5 TMEM239 TP53BP2 TRIM39 TRIM54 TRIM8 UBC UBE2D3 UBE2F UBE2M VPS37B	7 interacting genes: DCUN1D1 NUMA1 SHMT2 SMURF2 THAP5 UBC USP7
Entrez ID		54165	23172
HPRD ID		12067	13783
Ensembl ID		ENSG00000043093	ENSG00000165660
Uniprot IDs		B4DM76 C9JVE2 Q96GG9	Q15018
PDB IDs		3TDU 3TDZ 4P5O 5UFI 5V83 5V86 5V88 6B5Q 6BG3 6BG5 6P5V 6P5W	6H3C 6R8F
Enriched GO Terms of Interacting Partners?
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