DCUN1D1 and CUL5

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		DCUN1D1	CUL5
Description		defective in cullin neddylation 1 domain containing 1	cullin 5
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol	Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Site Of DNA Damage
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Ubiquitin-protein Transferase Activity Calcium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity
	Biological Process	Regulation Of Protein Ubiquitination Post-translational Protein Modification Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation	G1/S Transition Of Mitotic Cell Cycle Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ERBB2 Signaling Pathway Post-translational Protein Modification Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway
Pathways		Neddylation	Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Parkinson's disease ( 27182965 28011712) Subjective response to lithium treatment ( 26503763)	Refractive error ( 32231278)
Interacting Genes		33 interacting genes: ABRAXAS2 ARIH1 ARIH2 ARRDC3 AURKB CALM1 CAND1 CDIP1 CUL5 DAZAP2 DVL2 FAM168A GMPPA LAPTM5 LZTS2 MAP3K1 NEDD4 PLEKHB2 RHOA RNF11 SMAD2 SUSD6 TLE5 TMEM239 TP53BP2 TRIM39 TRIM54 TRIM8 UBC UBE2D3 UBE2F UBE2M VPS37B	36 interacting genes: ANAPC11 ASB11 CCNB1IP1 CCNDBP1 COG6 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D1 DEPTOR ELOA ERCC6 GHR GOLGA2 GPS1 KANK4 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RHOU RNF7 SMAD2 SMURF1 SOX30 TGFBR1 TRAF6 UBC UBE2F VHL
Entrez ID		54165	8065
HPRD ID		12067	03444
Ensembl ID		ENSG00000043093	ENSG00000166266
Uniprot IDs		B4DM76 C9JVE2 Q96GG9	Q93034
PDB IDs		3TDU 3TDZ 4P5O 5UFI 5V83 5V86 5V88 6B5Q 6BG3 6BG5 6P5V 6P5W	3DPL 3DQV 4JGH 4N9F 6V9I
Enriched GO Terms of Interacting Partners?
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