DCUN1D1 and ARIH1

Data Source:
BioGRID (enzymatic study)

		DCUN1D1	ARIH1
Description		defective in cullin neddylation 1 domain containing 1	ariadne RBR E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Cajal Body Nuclear Body SCF Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Lewy Body
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Protein Ubiquitination Post-translational Protein Modification Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Phosphopantetheinylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Neddylation	ISG15 antiviral mechanism
Drugs
Diseases
GWAS		Parkinson's disease ( 27182965 28011712) Subjective response to lithium treatment ( 26503763)
Interacting Genes		33 interacting genes: ABRAXAS2 ARIH1 ARIH2 ARRDC3 AURKB CALM1 CAND1 CDIP1 CUL5 DAZAP2 DVL2 FAM168A GMPPA LAPTM5 LZTS2 MAP3K1 NEDD4 PLEKHB2 RHOA RNF11 SMAD2 SUSD6 TLE5 TMEM239 TP53BP2 TRIM39 TRIM54 TRIM8 UBC UBE2D3 UBE2F UBE2M VPS37B	17 interacting genes: CCNE1 CDKN1B CRY1 DCUN1D1 EIF4E2 HSPB1 PLD1 RBX1 SEC31A UBC UBE2D1 UBE2D3 UBE2E2 UBE2L3 UBE2L6 UBE2N VAV2
Entrez ID		54165	25820
HPRD ID		12067	05730
Ensembl ID		ENSG00000043093	ENSG00000166233
Uniprot IDs		B4DM76 C9JVE2 Q96GG9	Q9Y4X5
PDB IDs		3TDU 3TDZ 4P5O 5UFI 5V83 5V86 5V88 6B5Q 6BG3 6BG5 6P5V 6P5W	1WD2 2M9Y 4KBL 4KC9 5TTE 5UDH
Enriched GO Terms of Interacting Partners?
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