ABRAXAS2 and NUMA1

Data Source:
BioGRID (pull down)

		ABRAXAS2	NUMA1
Description		abraxas 2, BRISC complex subunit	nuclear mitotic apparatus protein 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Midbody Spindle Pole Centrosome Microtubule Minus-end BRISC Complex	Golgi Membrane Spindle Pole Nucleus Nucleoplasm Chromosome Centrosome Spindle Cytosol Spindle Microtubule Cell Cortex Lateral Plasma Membrane Nuclear Matrix Extrinsic Component Of Plasma Membrane Dendrite Spindle Pole Centrosome Protein-containing Complex Microtubule Plus-end Microtubule Minus-end Neuronal Cell Body Cortical Microtubule Mitotic Spindle Astral Microtubule Extracellular Exosome Mitotic Spindle Microtubule Bundle Mitotic Spindle Pole Lateral Cell Cortex Cell Cortex Region Cytoplasmic Microtubule Bundle Mitotic Spindle Midzone
	Molecular Function	Protein Binding Microtubule Binding Polyubiquitin Modification-dependent Protein Binding	Structural Molecule Activity Protein Binding Microtubule Binding Protein C-terminus Binding Tubulin Binding Protein Domain Specific Binding Phosphatidylinositol Binding Protein-containing Complex Binding Microtubule Plus-end Binding Microtubule Minus-end Binding Dynein Complex Binding Disordered Domain Specific Binding
	Biological Process	Mitotic Cell Cycle Response To Ischemia Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Protein Deubiquitination Cell Division Protein K63-linked Deubiquitination Mitotic Spindle Assembly	Establishment Of Mitotic Spindle Orientation Microtubule Bundle Formation Nucleus Organization Chromosome Segregation Positive Regulation Of BMP Signaling Pathway Astral Microtubule Organization Positive Regulation Of Microtubule Polymerization Positive Regulation Of Intracellular Transport Positive Regulation Of Keratinocyte Differentiation Cell Division Meiotic Cell Cycle Positive Regulation Of Hair Follicle Development Positive Regulation Of Chromosome Segregation Anastral Spindle Assembly Regulation Of Mitotic Spindle Organization Regulation Of Metaphase Plate Congression Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Chromosome Separation Positive Regulation Of Spindle Assembly
Pathways		Metalloprotease DUBs	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
Drugs
Diseases
GWAS		Bone mineral content ( 31790847)	Antibody level in response to infection ( 25758998) Microalbuminuria ( 31511532) Severe influenza A (H1N1) infection ( 26379185) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		7 interacting genes: DCUN1D1 NUMA1 SHMT2 SMURF2 THAP5 UBC USP7	25 interacting genes: ABRAXAS2 ACTR1A BRAP BRCC3 CCDC57 CDK6 EPB41 EPB41L1 EPB41L2 ERG GMCL1 GNAI1 GPSM2 NCOA6 PIM1 RAD21 RAE1 SMC1A SUMO2 TERF1 TERF2 TERF2IP TNKS YEATS4 YWHAQ
Entrez ID		23172	4926
HPRD ID		13783	01236
Ensembl ID		ENSG00000165660	ENSG00000137497
Uniprot IDs		Q15018	A0A024R5M9 Q14980 Q3SYK8 Q4LE64
PDB IDs		6H3C 6R8F	3RO2 5GXW 6HC2 6QJA
Enriched GO Terms of Interacting Partners?
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