ORC2 and MCM3

Data Source:
BioGRID (biochemical)
HPRD (two hybrid, in vitro)

		ORC2	MCM3
Description		origin recognition complex subunit 2	minichromosome maintenance complex component 3
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Heterochromatin Origin Recognition Complex Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane	Chromosome, Telomeric Region Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Centrosome Membrane MCM Complex Perinuclear Region Of Cytoplasm CMG Complex
	Molecular Function	DNA Replication Origin Binding Protein Binding	DNA Binding DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Replication Initiation	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding Mitotic DNA Replication Initiation
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)
Interacting Genes		28 interacting genes: CDC45 CDC5L CDC6 CDK2 CDT1 CTNNA3 DBF4 EP300 H3-4 H4-16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RAD18 RIPPLY3 RPA1 RPA2 XRCC5	36 interacting genes: CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 EP300 HAUS1 KEAP1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 MCMBP ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B PTEN RAD52 STAT1 SUMO2 SUPT16H SYF2 TRIM28 YWHAQ
Entrez ID		4999	4172
HPRD ID		03112	04072
Ensembl ID		ENSG00000115942	ENSG00000112118
Uniprot IDs		A0A024R411 Q13416	A0A0S2Z4T1 A0A499FHX9 B4DUQ9 P25205
PDB IDs		5C8H 5UJ8 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS	6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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