MCM3 and RAD52

Data Source:
HPRD (in vitro, in vivo)

		MCM3	RAD52
Description		minichromosome maintenance complex component 3	RAD52 homolog, DNA repair protein
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Centrosome Membrane MCM Complex Perinuclear Region Of Cytoplasm CMG Complex	Nucleus Nucleoplasm Protein-containing Complex Protein-DNA Complex
	Molecular Function	DNA Binding DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding	DNA Binding Single-stranded DNA Binding Protein Binding Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding Mitotic DNA Replication Initiation	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly Double-strand Break Repair DNA Recombination Mitotic Recombination Cellular Response To DNA Damage Stimulus DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Cellular Response To Oxidative Stress Double-strand Break Repair Via Single-strand Annealing Regulation Of Nucleotide-excision Repair
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA)
Drugs
Diseases
GWAS			Blood protein levels ( 29875488) Body mass index ( 26426971) Eosinophil percentage of granulocytes ( 27863252) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lung cancer ( 22899653) Neutrophil percentage of granulocytes ( 27863252) Small cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653 30578418) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		36 interacting genes: CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 EP300 HAUS1 KEAP1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 MCMBP ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B PTEN RAD52 STAT1 SUMO2 SUPT16H SYF2 TRIM28 YWHAQ	25 interacting genes: ABL1 AURKB DCP1A ERCC1 ERCC2 ERCC3 ERCC4 KPNA3 KPNA5 MCM2 MCM3 MEOX1 MEOX2 NFYC PAX5 PLK3 RAD51 RDM1 RPA1 RPA2 SEM1 SUMO1 TTK UBE2I WRN
Entrez ID		4172	5893
HPRD ID		04072	11855
Ensembl ID		ENSG00000112118	ENSG00000002016
Uniprot IDs		A0A0S2Z4T1 A0A499FHX9 B4DUQ9 P25205	B7Z2G8 B7Z5Q6 F5GX32 P43351 Q5DR82
PDB IDs		6XTX 6XTY	1H2I 1KN0 5JRB 5XRZ 5XS0
Enriched GO Terms of Interacting Partners?
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