MCM3 and SYF2

Data Source:
BioGRID (pull down, pull down)

		MCM3	SYF2
Description		minichromosome maintenance complex component 3	SYF2 pre-mRNA splicing factor
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Centrosome Membrane MCM Complex Perinuclear Region Of Cytoplasm CMG Complex	Prp19 Complex Nucleus Nucleoplasm Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Post-mRNA Release Spliceosomal Complex
	Molecular Function	DNA Binding DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding	RNA Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding Mitotic DNA Replication Initiation	MRNA Splicing, Via Spliceosome In Utero Embryonic Development Mitotic G2 DNA Damage Checkpoint Gastrulation Positive Regulation Of Cell Population Proliferation Embryonic Organ Development
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Glycated hemoglobin levels ( 28898252) Lead levels ( 26025379) Male-pattern baldness ( 29146897 27182965) Mean corpuscular volume ( 27863252) Plateletcrit ( 27863252) Urate levels in obese individuals ( 25811787)
Interacting Genes		36 interacting genes: CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 EP300 HAUS1 KEAP1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 MCMBP ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B PTEN RAD52 STAT1 SUMO2 SUPT16H SYF2 TRIM28 YWHAQ	5 interacting genes: APP ARMC7 CCNDBP1 MCM3 MLH1
Entrez ID		4172	25949
HPRD ID		04072	07386
Ensembl ID		ENSG00000112118	ENSG00000117614
Uniprot IDs		A0A0S2Z4T1 A0A499FHX9 B4DUQ9 P25205	O95926
PDB IDs		6XTX 6XTY	5MQF 5XJC 5YZG 6ICZ 6ID0 6ID1 6QDV 7A5P
Enriched GO Terms of Interacting Partners?
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