ORC2 and MCM5

Data Source:
BioGRID (biochemical, two hybrid)
HPRD (two hybrid)

		ORC2	MCM5
Description		origin recognition complex subunit 2	minichromosome maintenance complex component 5
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Heterochromatin Origin Recognition Complex Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Membrane MCM Complex CMG Complex
	Molecular Function	DNA Replication Origin Binding Protein Binding	DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Single-stranded DNA Helicase Activity 3'-5' DNA Helicase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Replication Initiation	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Replication Initiation DNA Duplex Unwinding
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)	Chronotype ( 30696823) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		28 interacting genes: CDC45 CDC5L CDC6 CDK2 CDT1 CTNNA3 DBF4 EP300 H3-4 H4-16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RAD18 RIPPLY3 RPA1 RPA2 XRCC5	28 interacting genes: APP CDC5L CDC7 CDKN2A EP300 ESCO2 FBXO7 KRTAP10-7 LMNA MCM2 MCM3 MCM7 MCMBP MCPH1 MDFI NFKBIA NUDT3 ORC1 ORC2 ORC3 ORC5 ORC6 PTEN RBPMS RPA2 STAT1 TRIM28 YWHAG
Entrez ID		4999	4174
HPRD ID		03112	04075
Ensembl ID		ENSG00000115942	ENSG00000100297
Uniprot IDs		A0A024R411 Q13416	B1AHB0 P33992
PDB IDs		5C8H 5UJ8 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS	6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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