ORC2 and RIPPLY3

Data Source:
BioGRID (two hybrid)

		ORC2	RIPPLY3
Description		origin recognition complex subunit 2	ripply transcriptional repressor 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Heterochromatin Origin Recognition Complex Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane	Nucleus
	Molecular Function	DNA Replication Origin Binding Protein Binding	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Replication Initiation	Negative Regulation Of Transcription By RNA Polymerase II Heart Development Biological_process Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Pharyngeal System Development
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)
Interacting Genes		28 interacting genes: CDC45 CDC5L CDC6 CDK2 CDT1 CTNNA3 DBF4 EP300 H3-4 H4-16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RAD18 RIPPLY3 RPA1 RPA2 XRCC5	7 interacting genes: CEP76 INCA1 MCRS1 ORC2 PSMB1 TIFA TRAF2
Entrez ID		4999	53820
HPRD ID		03112	10923
Ensembl ID		ENSG00000115942	ENSG00000183145
Uniprot IDs		A0A024R411 Q13416	P57055
PDB IDs		5C8H 5UJ8 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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