NDUFS3 and GZMA

Data Source:
BioGRID (enzymatic study)

		NDUFS3	GZMA
Description		NADH:ubiquinone oxidoreductase core subunit S3	granzyme A
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Respiratory Chain Complex I Mitochondrial Matrix Nuclear Body Mitochondrial Membrane	Immunological Synapse Extracellular Region Nucleus
	Molecular Function	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity	Serine-type Endopeptidase Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Substantia Nigra Development Negative Regulation Of Cell Growth Mitochondrial Respiratory Chain Complex I Assembly Reactive Oxygen Species Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Apoptotic Process Immune Response Response To Bacterium Cytolysis Negative Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Oxidoreductase Activity Proteolysis Involved In Cellular Protein Catabolic Process Pyroptosis Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Process
Pathways		Respiratory electron transport Complex I biogenesis
Drugs		NADH
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Adult body size ( 32376654) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 20935630) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Fruit consumption ( 32066663) Height ( 28552196) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mood instability ( 31168069) Neuroticism ( 29255261) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698)
Interacting Genes		4 interacting genes: GZMA NDUFA5 RASL10B TMEM11	17 interacting genes: ACTG1 APEX1 GOLGA2 H1-1 H2BC21 HDC HMGB2 HNRNPK HSP90AA1 HSPA4 LMNA LMNB1 NCL NDUFS3 SET XRCC5 XRCC6
Entrez ID		4722	3001
HPRD ID		10355	00771
Ensembl ID		ENSG00000213619	ENSG00000145649
Uniprot IDs		O75489	P12544
PDB IDs		5XTB 5XTD 5XTH 5XTI	1HF1 1OP8 1ORF
Enriched GO Terms of Interacting Partners?
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