NDUFS3 and NDUFA5

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		NDUFS3	NDUFA5
Description		NADH:ubiquinone oxidoreductase core subunit S3	NADH:ubiquinone oxidoreductase subunit A5
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Respiratory Chain Complex I Mitochondrial Matrix Nuclear Body Mitochondrial Membrane	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I
	Molecular Function	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity	Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Substantia Nigra Development Negative Regulation Of Cell Growth Mitochondrial Respiratory Chain Complex I Assembly Reactive Oxygen Species Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Mitochondrial Electron Transport, NADH To Ubiquinone Respiratory Electron Transport Chain Mitochondrial Respiratory Chain Complex I Assembly
Pathways		Respiratory electron transport Complex I biogenesis	Respiratory electron transport Complex I biogenesis
Drugs		NADH	NADH
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Adult body size ( 32376654) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 20935630) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Fruit consumption ( 32066663) Height ( 28552196) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mood instability ( 31168069) Neuroticism ( 29255261) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698)
Interacting Genes		4 interacting genes: GZMA NDUFA5 RASL10B TMEM11	10 interacting genes: APP CBY2 CCDC85B COG6 DAZAP2 GOLGA2 NDUFB1 NDUFS3 PLEKHF2 TTR
Entrez ID		4722	4698
HPRD ID		10355	03398
Ensembl ID		ENSG00000213619	ENSG00000128609
Uniprot IDs		O75489	A0A024R745 A0A087WXR5 A0A087X1G1 Q16718
PDB IDs		5XTB 5XTD 5XTH 5XTI	5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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