NDUFS3 and TMEM11

Data Source:
BioGRID (two hybrid)

		NDUFS3	TMEM11
Description		NADH:ubiquinone oxidoreductase core subunit S3	transmembrane protein 11
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Respiratory Chain Complex I Mitochondrial Matrix Nuclear Body Mitochondrial Membrane	Mitochondrion Integral Component Of Plasma Membrane Integral Component Of Mitochondrial Inner Membrane
	Molecular Function	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity	Molecular_function Protein Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Substantia Nigra Development Negative Regulation Of Cell Growth Mitochondrial Respiratory Chain Complex I Assembly Reactive Oxygen Species Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Mitochondrion Organization Inner Mitochondrial Membrane Organization
Pathways		Respiratory electron transport Complex I biogenesis	Cristae formation
Drugs		NADH
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Adult body size ( 32376654) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 20935630) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Fruit consumption ( 32066663) Height ( 28552196) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mood instability ( 31168069) Neuroticism ( 29255261) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698)	Body mass index ( 26426971) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: GZMA NDUFA5 RASL10B TMEM11	53 interacting genes: ARL13B BDKRB2 BIK BNIP3 BNIP3L CCDC70 CCR4 CD79A CLDN7 CLN8 CREB3L1 CYB561 CYB5D2 DRD2 EBP ELOVL4 FAM174A FAM209A FAM210B FATE1 FFAR2 GJB4 GORAB KASH5 LEPROTL1 LMNA MRM1 MSMO1 MTIF3 MUC1 NDUFS3 OTX2 PDZK1IP1 PEX12 RETREG3 RIC3 RNASEH1 SCMH1 SGCB SLC10A6 SLC30A8 SUSD3 SUV39H1 TEX29 TMEM106C TMEM14B TMEM205 TMEM237 TMEM88 TMIE TMPRSS2 TNFSF14 YIPF6
Entrez ID		4722	8834
HPRD ID		10355	12680
Ensembl ID		ENSG00000213619	ENSG00000178307
Uniprot IDs		O75489	P17152
PDB IDs		5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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