MBD1 and CBX5

Data Source:
HPRD (in vivo, in vitro)

		MBD1	CBX5
Description		methyl-CpG binding domain protein 1	chromobox 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Matrix Nuclear Speck	Histone Deacetylase Complex Kinetochore Chromosome, Telomeric Region Heterochromatin Nucleus Nuclear Envelope Nucleoplasm Pericentric Heterochromatin Nucleolus Chromocenter PML Body Transcription Repressor Complex Protein-containing Complex Histone Methyltransferase Complex Site Of DNA Damage Ribonucleoprotein Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Unmethylated CpG Binding	Chromatin Binding Protein Binding Protein-macromolecule Adaptor Activity Methylated Histone Binding Identical Protein Binding Histone Deacetylase Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding Repressing Transcription Factor Binding
	Biological Process	Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Blood Coagulation Viral Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition
Pathways		SUMOylation of transcription cofactors	SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production
Drugs			Copper
Diseases
GWAS		Chronic lymphocytic leukemia ( 28165464)	Adult body size ( 32376654) Alcohol consumption ( 31358974) Hip circumference ( 28552196) Mean platelet volume ( 22139419) Meat-related diet ( 32066663) Platelet count ( 32888494) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		25 interacting genes: APP ATF7IP ATF7IP2 ATXN1L CBX4 CBX5 CHAF1A ECT2 HDAC3 HIPK3 HTT OASL PIAS1 PIAS2 RNF2 SETDB1 SMAD1 SMAD3 SMAD5 SMAD7 SMAD9 SP1 SUV39H1 TENM1 ZNF512B	59 interacting genes: ARHGDIA ARL5A BAP1 BARD1 BCL11B BRCA1 CBX1 CBX3 CHAF1A DNMT3B DSN1 ELOA2 ELOC ENO1 FSHR GOLGA8EP H1-4 H1-5 H2AW H2BU1 H3-4 H3C15 H4-16 HDAC4 HDAC5 HDAC9 HECW2 INCENP LAP3 LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSD3 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 TAF4 TRIM24 TRIM28 UBE2A UBE2B VPS28 XRCC6 XRN1 ZNF280C ZNF280D
Entrez ID		4152	23468
HPRD ID		01133	05131
Ensembl ID		ENSG00000141644	ENSG00000094916
Uniprot IDs		A8K654 B4DI41 B4DUR3 Q9UIS9	P45973 V9HWG0
PDB IDs		1D9N 1IG4 4D4W 5W9Q 6D1T	3FDT 3I3C
Enriched GO Terms of Interacting Partners?
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