MBD1 and ATF7IP

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		MBD1	ATF7IP
Description		methyl-CpG binding domain protein 1	activating transcription factor 7 interacting protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Matrix Nuclear Speck	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Nuclear Body
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Unmethylated CpG Binding	Transcription Corepressor Activity Protein Binding ATPase Activity
	Biological Process	Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Viral Process Regulation Of Protein Stability Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Protein Stabilization Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly
Pathways		SUMOylation of transcription cofactors	PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 28165464)	Breast cancer ( 24143190) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Height ( 31562340) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Leukocyte telomere length ( 32109421) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate-specific antigen levels ( 23359319) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 28604728 28604732 23666240)
Interacting Genes		25 interacting genes: APP ATF7IP ATF7IP2 ATXN1L CBX4 CBX5 CHAF1A ECT2 HDAC3 HIPK3 HTT OASL PIAS1 PIAS2 RNF2 SETDB1 SMAD1 SMAD3 SMAD5 SMAD7 SMAD9 SP1 SUV39H1 TENM1 ZNF512B	70 interacting genes: A2M ACTB ACTG1 AP1B1 CADM1 CEP250 COL4A2 CREB1 CREBBP CSPG4 DISC1 DMTF1 DNM2 EHMT2 EPG5 FLNB FLT4 GMEB1 GTF2E2 GTF2F1 GTF2H1 HEYL HLA-B HSPG2 KIF13A KRT7 LAMA4 LAMA5 LAMC1 LUC7L2 MACF1 MBD1 MCAM MED4 MRI1 NOMO1 NPR1 PAPPA PAPPA2 PCDH1 PEX6 PIAS3 PKD1 PLEKHB2 POLR2C POLR2D POLR2G PRSS8 PSG3 QRICH1 RPS3A RRBP1 SENP3 SETDB1 SLC12A4 SMAD4 SP1 SPTBN1 SREBF2 STBD1 STRN SUMO2 SUSD1 SVEP1 TRIP12 TTC3 UBE2I ZBTB6 ZNF350 ZNF518A
Entrez ID		4152	55729
HPRD ID		01133	09811
Ensembl ID		ENSG00000141644	ENSG00000171681
Uniprot IDs		A8K654 B4DI41 B4DUR3 Q9UIS9	A0A024RAY1 B3KNI7 B3KQF8 Q6VMQ6
PDB IDs		1D9N 1IG4 4D4W 5W9Q 6D1T	2RPQ
Enriched GO Terms of Interacting Partners?
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