CBX5 and DSN1

Data Source:
HPRD (in vivo)

		CBX5	DSN1
Description		chromobox 5	DSN1 component of MIS12 kinetochore complex
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GO Annotations	Cellular Component	Histone Deacetylase Complex Kinetochore Chromosome, Telomeric Region Heterochromatin Nucleus Nuclear Envelope Nucleoplasm Pericentric Heterochromatin Nucleolus Chromocenter PML Body Transcription Repressor Complex Protein-containing Complex Histone Methyltransferase Complex Site Of DNA Damage Ribonucleoprotein Complex	MIS12/MIND Type Complex Kinetochore Condensed Chromosome Kinetochore Nuclear MIS12/MIND Complex Condensed Nuclear Chromosome Inner Kinetochore Fibrillar Center Extracellular Region Nucleoplasm Nucleolus Cytosol Nuclear Body Azurophil Granule Lumen
	Molecular Function	Chromatin Binding Protein Binding Protein-macromolecule Adaptor Activity Methylated Histone Binding Identical Protein Binding Histone Deacetylase Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding Repressing Transcription Factor Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Blood Coagulation Viral Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition	Mitotic Sister Chromatid Segregation Neutrophil Degranulation Cell Division
Pathways		SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Neutrophil degranulation Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Copper
Diseases
GWAS		Adult body size ( 32376654) Alcohol consumption ( 31358974) Hip circumference ( 28552196) Mean platelet volume ( 22139419) Meat-related diet ( 32066663) Platelet count ( 32888494) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Factor VII activity ( 30642921) Hallux valgus ( 32131869)
Interacting Genes		59 interacting genes: ARHGDIA ARL5A BAP1 BARD1 BCL11B BRCA1 CBX1 CBX3 CHAF1A DNMT3B DSN1 ELOA2 ELOC ENO1 FSHR GOLGA8EP H1-4 H1-5 H2AW H2BU1 H3-4 H3C15 H4-16 HDAC4 HDAC5 HDAC9 HECW2 INCENP LAP3 LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSD3 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 TAF4 TRIM24 TRIM28 UBE2A UBE2B VPS28 XRCC6 XRN1 ZNF280C ZNF280D	12 interacting genes: AIMP2 APP CBX3 CBX5 HGS KNL1 MIS12 NSL1 PIK3R3 PMF1 SUGT1 ZWINT
Entrez ID		23468	79980
HPRD ID		05131	16455
Ensembl ID		ENSG00000094916	ENSG00000149636
Uniprot IDs		P45973 V9HWG0	A8K3X3 Q9H410
PDB IDs		3FDT 3I3C	5LSI 5LSJ 5LSK
Enriched GO Terms of Interacting Partners?
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