CBX5 and PRR14

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)
HPRD (two hybrid)

		CBX5	PRR14
Description		chromobox 5	proline rich 14
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Kinetochore Chromosome, Telomeric Region Heterochromatin Nucleus Nuclear Envelope Nucleoplasm Pericentric Heterochromatin Nucleolus Chromocenter PML Body Transcription Repressor Complex Protein-containing Complex Histone Methyltransferase Complex Site Of DNA Damage Ribonucleoprotein Complex	Nuclear Lamina Nucleoplasm Chromosome
	Molecular Function	Chromatin Binding Protein Binding Protein-macromolecule Adaptor Activity Methylated Histone Binding Identical Protein Binding Histone Deacetylase Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding Repressing Transcription Factor Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Blood Coagulation Viral Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition	Muscle Organ Development
Pathways		SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production
Drugs		Copper
Diseases
GWAS		Adult body size ( 32376654) Alcohol consumption ( 31358974) Hip circumference ( 28552196) Mean platelet volume ( 22139419) Meat-related diet ( 32066663) Platelet count ( 32888494) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Immunoglobulin light chain (AL) amyloidosis ( 28025584) Irritable mood ( 29500382) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neurociticism ( 29500382)
Interacting Genes		59 interacting genes: ARHGDIA ARL5A BAP1 BARD1 BCL11B BRCA1 CBX1 CBX3 CHAF1A DNMT3B DSN1 ELOA2 ELOC ENO1 FSHR GOLGA8EP H1-4 H1-5 H2AW H2BU1 H3-4 H3C15 H4-16 HDAC4 HDAC5 HDAC9 HECW2 INCENP LAP3 LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSD3 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 TAF4 TRIM24 TRIM28 UBE2A UBE2B VPS28 XRCC6 XRN1 ZNF280C ZNF280D	5 interacting genes: APP CBX3 CBX5 SH3BP4 SH3GL2
Entrez ID		23468	78994
HPRD ID		05131	14541
Ensembl ID		ENSG00000094916	ENSG00000156858
Uniprot IDs		P45973 V9HWG0	A0A024QZB5 Q9BWN1
PDB IDs		3FDT 3I3C
Enriched GO Terms of Interacting Partners?
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