CBX5 and NIPBL

Data Source:
BioGRID (unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		CBX5	NIPBL
Description		chromobox 5	NIPBL cohesin loading factor
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GO Annotations	Cellular Component	Histone Deacetylase Complex Kinetochore Chromosome, Telomeric Region Heterochromatin Nucleus Nuclear Envelope Nucleoplasm Pericentric Heterochromatin Nucleolus Chromocenter PML Body Transcription Repressor Complex Protein-containing Complex Histone Methyltransferase Complex Site Of DNA Damage Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytosol Integrator Complex SMC Loading Complex Intracellular Membrane-bounded Organelle Extracellular Exosome Scc2-Scc4 Cohesin Loading Complex
	Molecular Function	Chromatin Binding Protein Binding Protein-macromolecule Adaptor Activity Methylated Histone Binding Identical Protein Binding Histone Deacetylase Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding Repressing Transcription Factor Binding	Chromatin Binding Protein Binding Protein C-terminus Binding Mediator Complex Binding Histone Deacetylase Binding Protein N-terminus Binding Chromo Shadow Domain Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Blood Coagulation Viral Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Heart Morphogenesis Outflow Tract Morphogenesis Cellular Response To DNA Damage Stimulus Mitotic Sister Chromatid Cohesion Brain Development Sensory Perception Of Sound Stem Cell Population Maintenance Positive Regulation Of Histone Deacetylation Establishment Of Mitotic Sister Chromatid Cohesion Maintenance Of Mitotic Sister Chromatid Cohesion Cellular Protein Localization Embryonic Forelimb Morphogenesis Forelimb Morphogenesis External Genitalia Morphogenesis Positive Regulation Of Multicellular Organism Growth Ear Morphogenesis Regulation Of Hair Cycle Fat Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated Regulation Of Embryonic Development Embryonic Digestive Tract Morphogenesis Digestive Tract Development Developmental Growth Eye Morphogenesis Regulation Of Developmental Growth Embryonic Viscerocranium Morphogenesis Cognition Face Morphogenesis Gall Bladder Development Uterus Morphogenesis Establishment Of Protein Localization To Chromatin Cellular Response To X-ray Transcriptional Activation By Promoter-enhancer Looping Cohesin Loading Positive Regulation Of Mitotic Cohesin Loading Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Positive Regulation Of Neuron Migration
Pathways		SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production	Cohesin Loading onto Chromatin
Drugs		Copper
Diseases			Cornelia de Lange syndrome (CdLS)
GWAS		Adult body size ( 32376654) Alcohol consumption ( 31358974) Hip circumference ( 28552196) Mean platelet volume ( 22139419) Meat-related diet ( 32066663) Platelet count ( 32888494) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Height ( 28552196 25282103 31562340) Malaria ( 31844061) Meat-related diet ( 32066663) Obesity-related traits ( 23251661) Weight ( 28552196)
Interacting Genes		59 interacting genes: ARHGDIA ARL5A BAP1 BARD1 BCL11B BRCA1 CBX1 CBX3 CHAF1A DNMT3B DSN1 ELOA2 ELOC ENO1 FSHR GOLGA8EP H1-4 H1-5 H2AW H2BU1 H3-4 H3C15 H4-16 HDAC4 HDAC5 HDAC9 HECW2 INCENP LAP3 LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSD3 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 TAF4 TRIM24 TRIM28 UBE2A UBE2B VPS28 XRCC6 XRN1 ZNF280C ZNF280D	7 interacting genes: CBX5 CDK6 DBN1 HINFP PRSS23 SP100 SUMO2
Entrez ID		23468	25836
HPRD ID		05131	10560
Ensembl ID		ENSG00000094916	ENSG00000164190
Uniprot IDs		P45973 V9HWG0	A0A590UJS4 Q6KC79
PDB IDs		3FDT 3I3C	6WG3 6WGE
Enriched GO Terms of Interacting Partners?
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