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L1CAM and NRP2
Data Source:
BioGRID
(two hybrid)
L1CAM
NRP2
Description
L1 cell adhesion molecule
neuropilin 2
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
Cell Surface
Integral Component Of Membrane
Axon
Dendrite
Neuronal Cell Body
Axonal Growth Cone
Collagen-containing Extracellular Matrix
Semaphorin Receptor Complex
Extracellular Region
Plasma Membrane
Membrane
Integral Component Of Membrane
Axon
Glutamatergic Synapse
Integral Component Of Postsynaptic Membrane
Molecular Function
Protein Binding
Axon Guidance Receptor Activity
Protein Domain Specific Binding
Vascular Endothelial Growth Factor-activated Receptor Activity
Protein Binding
Heparin Binding
Semaphorin Receptor Activity
Growth Factor Binding
Cytokine Binding
Signaling Receptor Activity
Metal Ion Binding
Biological Process
Chemotaxis
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Cell-matrix Adhesion
Nervous System Development
Axon Guidance
Cell Migration
Neuron Projection Development
Positive Regulation Of Axon Extension
Synapse Organization
Leukocyte Migration
Axon Development
Angiogenesis
Positive Regulation Of Endothelial Cell Proliferation
Outflow Tract Septum Morphogenesis
Cell Adhesion
Axon Guidance
Positive Regulation Of Endothelial Cell Migration
Viral Process
Facial Nerve Structural Organization
Vestibulocochlear Nerve Structural Organization
Nerve Development
Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus
Ventral Trunk Neural Crest Cell Migration
Vascular Endothelial Growth Factor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Axon Extension Involved In Axon Guidance
Negative Chemotaxis
Sympathetic Ganglion Development
Trigeminal Ganglion Development
Sensory Neuron Axon Guidance
Sympathetic Neuron Projection Extension
Sympathetic Neuron Projection Guidance
Regulation Of Postsynapse Organization
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance
Facioacoustic Ganglion Development
Dorsal Root Ganglion Morphogenesis
Cellular Response To Leukemia Inhibitory Factor
Pathways
Basigin interactions
L1CAM interactions
L1CAM interactions
Recycling pathway of L1
Recycling pathway of L1
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
Signal transduction by L1
Neurophilin interactions with VEGF and VEGFR
NrCAM interactions
Drugs
Ethanol
Diseases
Hereditary spastic paraplegia (SPG)
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
L1 syndrome, including: ; X-linked hydrocephalus; MASA syndrome; X-linked complicated spastic paraplegia type I ; X-linked partial agenesis of corpus callosum
GWAS
Blood protein levels (
30072576
29875488
)
Craniofacial microsomia (
26853712
)
Diisocyanate-induced asthma (
25918132
)
Neuropathy x type 2 diabetes interaction (
32541925
)
Interacting Genes
24 interacting genes:
ANK1
ANK2
CNTN1
CNTN2
CSNK2A1
EZR
FGFR1
ITGA5
ITGAV
LINC00839
MSN
NCAM1
NCAN
NRP1
NRP2
NUMB
PEA15
PLXNA1
PLXNB1
PRNP
RANBP9
RDX
RPS6KA1
RPS6KA2
11 interacting genes:
FLT1
L1CAM
NRP1
PGF
PLXNA1
PLXNB1
SEMA3B
SEMA3C
SEMA3F
SEMA4F
VEGFA
Entrez ID
3897
8828
HPRD ID
02394
03643
Ensembl ID
ENSG00000198910
ENSG00000118257
Uniprot IDs
P32004
O60462
Q7Z3T9
PDB IDs
2QQJ
2QQK
2QQL
2QQO
4QDQ
4QDR
4QDS
5DN2
5DQ0
6GH8
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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