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L1CAM and EZR
Data Source:
BioGRID
(pull down, affinity chromatography technology)
HPRD
(in vivo)
L1CAM
EZR
Description
L1 cell adhesion molecule
ezrin
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
Cell Surface
Integral Component Of Membrane
Axon
Dendrite
Neuronal Cell Body
Axonal Growth Cone
Collagen-containing Extracellular Matrix
Fibrillar Center
Ruffle
Immunological Synapse
Uropod
Extracellular Space
Cytoplasm
Endosome
Cytosol
Actin Filament
Plasma Membrane
Microvillus
Brush Border
Focal Adhesion
Actin Cytoskeleton
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Extrinsic Component Of Membrane
Filopodium
T-tubule
Cortical Cytoskeleton
Microvillus Membrane
Vesicle
Ruffle Membrane
Protein-containing Complex
Ciliary Basal Body
Cell Projection
Cell Body
Microspike
Plasma Membrane Raft
Apical Part Of Cell
Perinuclear Region Of Cytoplasm
Cell Tip
Extracellular Exosome
Cell Periphery
Astrocyte Projection
Schwann Cell Microvillus
Cytoplasmic Side Of Apical Plasma Membrane
Molecular Function
Protein Binding
Axon Guidance Receptor Activity
Protein Domain Specific Binding
RNA Binding
Actin Binding
Protein Binding
Microtubule Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Protein Kinase A Catalytic Subunit Binding
Protein Kinase A Regulatory Subunit Binding
Identical Protein Binding
S100 Protein Binding
Cadherin Binding
Cell Adhesion Molecule Binding
Actin Filament Binding
Protein Kinase A Binding
ATPase Binding
Disordered Domain Specific Binding
Biological Process
Chemotaxis
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Cell-matrix Adhesion
Nervous System Development
Axon Guidance
Cell Migration
Neuron Projection Development
Positive Regulation Of Axon Extension
Synapse Organization
Leukocyte Migration
Axon Development
Negative Regulation Of Transcription By RNA Polymerase II
Intestinal D-glucose Absorption
Sphingosine-1-phosphate Receptor Signaling Pathway
Leukocyte Cell-cell Adhesion
Axon Guidance
Regulation Of Cell Shape
Regulation Of Cell Size
Positive Regulation Of Gene Expression
Protein Kinase A Signaling
Gland Morphogenesis
Membrane To Membrane Docking
Microvillus Assembly
Astral Microtubule Organization
Actin Cytoskeleton Reorganization
Receptor Internalization
Regulation Of Microvillus Length
Negative Regulation Of Interleukin-2 Production
Regulation Of Actin Cytoskeleton Organization
Cellular Protein-containing Complex Localization
Positive Regulation Of Multicellular Organism Growth
Cortical Microtubule Organization
Establishment Of Epithelial Cell Apical/basal Polarity
Filopodium Assembly
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Protein Secretion
Negative Regulation Of T Cell Receptor Signaling Pathway
Actin Filament Bundle Assembly
Establishment Of Centrosome Localization
Establishment Of Endothelial Barrier
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Protein Localization To Plasma Membrane
Protein Localization To Cell Cortex
Regulation Of NIK/NF-kappaB Signaling
Regulation Of Organelle Assembly
Terminal Web Assembly
Positive Regulation Of Protein Localization To Early Endosome
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of P38MAPK Cascade
Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways
Basigin interactions
L1CAM interactions
L1CAM interactions
Recycling pathway of L1
Recycling pathway of L1
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
Signal transduction by L1
Netrin-1 signaling
Recycling pathway of L1
Recycling pathway of L1
Drugs
Ethanol
Diseases
Hereditary spastic paraplegia (SPG)
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
L1 syndrome, including: ; X-linked hydrocephalus; MASA syndrome; X-linked complicated spastic paraplegia type I ; X-linked partial agenesis of corpus callosum
GWAS
Bladder cancer (smoking interaction) (
24662972
)
Blond vs. brown/black hair color (
30531825
)
Brown vs. black hair color (
30531825
)
Hair color (
29662168
)
Refractive error (
32231278
)
Interacting Genes
24 interacting genes:
ANK1
ANK2
CNTN1
CNTN2
CSNK2A1
EZR
FGFR1
ITGA5
ITGAV
LINC00839
MSN
NCAM1
NCAN
NRP1
NRP2
NUMB
PEA15
PLXNA1
PLXNB1
PRNP
RANBP9
RDX
RPS6KA1
RPS6KA2
55 interacting genes:
ACTB
ACTC1
ADORA2B
ADRA1B
ARF6
ARHGDIB
CD44
CDH1
CDK5
CFTR
CLIC5
CTNNB1
DLG1
EGFR
ERBB3
FAS
FASLG
GZMM
ICAM1
ICAM2
ICAM3
IQGAP1
L1CAM
LCK
MDM2
MISP
MME
MPP3
MSN
NF2
PALLD
PIK3R1
PRKAR2A
PRKCA
PTK2
PTPRC
RDX
ROCK1
S100P
SCYL3
SDC2
SELL
SELP
SLC9A3R1
SLC9A3R2
SPN
SUMO2
TBC1D10A
TMEM8B
TSC1
USP1
VCAM1
VPS11
WFDC1
WWOX
Entrez ID
3897
7430
HPRD ID
02394
00475
Ensembl ID
ENSG00000198910
ENSG00000092820
Uniprot IDs
P32004
P15311
PDB IDs
1NI2
4RM8
4RM9
4RMA
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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