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L1CAM and PLXNA1
Data Source:
BioGRID
(two hybrid)
L1CAM
PLXNA1
Description
L1 cell adhesion molecule
plexin A1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
Cell Surface
Integral Component Of Membrane
Axon
Dendrite
Neuronal Cell Body
Axonal Growth Cone
Collagen-containing Extracellular Matrix
Semaphorin Receptor Complex
Nucleoplasm
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Extracellular Exosome
Molecular Function
Protein Binding
Axon Guidance Receptor Activity
Protein Domain Specific Binding
Semaphorin Receptor Activity
Signaling Receptor Activity
Biological Process
Chemotaxis
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Cell-matrix Adhesion
Nervous System Development
Axon Guidance
Cell Migration
Neuron Projection Development
Positive Regulation Of Axon Extension
Synapse Organization
Leukocyte Migration
Axon Development
Negative Regulation Of Cell Adhesion
Multicellular Organism Development
Regulation Of Cell Shape
Regulation Of Smooth Muscle Cell Migration
Regulation Of Cell Migration
Regulation Of GTPase Activity
Positive Regulation Of Axonogenesis
Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching
Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Neuron Projection Extension
Pathways
Basigin interactions
L1CAM interactions
L1CAM interactions
Recycling pathway of L1
Recycling pathway of L1
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
Signal transduction by L1
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Other semaphorin interactions
Drugs
Ethanol
Diseases
Hereditary spastic paraplegia (SPG)
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
L1 syndrome, including: ; X-linked hydrocephalus; MASA syndrome; X-linked complicated spastic paraplegia type I ; X-linked partial agenesis of corpus callosum
GWAS
Alcoholic chronic pancreatitis (
28754779
)
Blood protein levels (
30072576
29875488
)
Platelet count (
32888494
)
Refractive error (
32231278
)
Systolic blood pressure (
31469255
)
Weight (
28552196
)
Whole-brain volume (
21116278
)
Interacting Genes
24 interacting genes:
ANK1
ANK2
CNTN1
CNTN2
CSNK2A1
EZR
FGFR1
ITGA5
ITGAV
LINC00839
MSN
NCAM1
NCAN
NRP1
NRP2
NUMB
PEA15
PLXNA1
PLXNB1
PRNP
RANBP9
RDX
RPS6KA1
RPS6KA2
9 interacting genes:
AKT1
FES
L1CAM
NRP1
NRP2
PLXNB1
RHOD
RND1
SEMA6D
Entrez ID
3897
5361
HPRD ID
02394
11868
Ensembl ID
ENSG00000198910
ENSG00000114554
Uniprot IDs
P32004
Q9UIW2
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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