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L1CAM and ANK2
Data Source:
HPRD
(in vivo)
L1CAM
ANK2
Description
L1 cell adhesion molecule
ankyrin 2
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
Cell Surface
Integral Component Of Membrane
Axon
Dendrite
Neuronal Cell Body
Axonal Growth Cone
Collagen-containing Extracellular Matrix
Mitochondrion
Lysosome
Early Endosome
Cytosol
Cytoskeleton
Plasma Membrane
Intercalated Disc
Basolateral Plasma Membrane
Apical Plasma Membrane
Z Disc
T-tubule
M Band
A Band
Sarcolemma
Neuron Projection
Costamere
Postsynaptic Membrane
Recycling Endosome
Molecular Function
Protein Binding
Axon Guidance Receptor Activity
Protein Domain Specific Binding
Protein Binding
Cytoskeletal Anchor Activity
Enzyme Binding
Protein Kinase Binding
Spectrin Binding
Protein-macromolecule Adaptor Activity
Ion Channel Binding
ATPase Binding
Phosphorylation-dependent Protein Binding
Biological Process
Chemotaxis
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Cell-matrix Adhesion
Nervous System Development
Axon Guidance
Cell Migration
Neuron Projection Development
Positive Regulation Of Axon Extension
Synapse Organization
Leukocyte Migration
Axon Development
Regulation Of Heart Rate
Atrial Septum Development
Cellular Calcium Ion Homeostasis
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Endocytosis
Positive Regulation Of Gene Expression
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling
Protein Transport
Regulation Of Protein Stability
T-tubule Organization
Protein Localization To Organelle
Protein Localization To Cell Surface
Cellular Protein Localization
Protein Localization To M-band
Protein Localization To T-tubule
Positive Regulation Of Potassium Ion Transport
Protein Stabilization
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Calcium Ion Transport
Positive Regulation Of Calcium Ion Transport
Regulation Of Cardiac Muscle Contraction
Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization
Sarcoplasmic Reticulum Calcium Ion Transport
Protein Localization To Endoplasmic Reticulum
Protein Localization To Plasma Membrane
Regulation Of Cardiac Muscle Cell Contraction
Ventricular Cardiac Muscle Cell Action Potential
Atrial Cardiac Muscle Cell Action Potential
SA Node Cell Action Potential
Membrane Depolarization During SA Node Cell Action Potential
Atrial Cardiac Muscle Cell To AV Node Cell Communication
SA Node Cell To Atrial Cardiac Muscle Cell Communication
Regulation Of Heart Rate By Cardiac Conduction
Regulation Of SA Node Cell Action Potential
Regulation Of Atrial Cardiac Muscle Cell Action Potential
Positive Regulation Of Potassium Ion Transmembrane Transporter Activity
Regulation Of Calcium Ion Transmembrane Transporter Activity
Positive Regulation Of Calcium Ion Transmembrane Transporter Activity
Positive Regulation Of Cation Channel Activity
Pathways
Basigin interactions
L1CAM interactions
L1CAM interactions
Recycling pathway of L1
Recycling pathway of L1
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
Signal transduction by L1
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
COPI-mediated anterograde transport
Drugs
Ethanol
Diseases
Hereditary spastic paraplegia (SPG)
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
L1 syndrome, including: ; X-linked hydrocephalus; MASA syndrome; X-linked complicated spastic paraplegia type I ; X-linked partial agenesis of corpus callosum
Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS
Blood trace element (Cu levels) (
23720494
)
Body mass index (
26426971
)
Chronotype (
30696823
)
Diastolic blood pressure (
31469255
)
Fractional exhaled nitric oxide (childhood) (
24315451
)
Gut microbiota relative abundance (Coprococcus) (
33208821
)
Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) (
33208821
)
Ischemic stroke (
29531354
)
Parkinson's disease (
28892059
)
Periventricular white matter hyperintensities (
32517579
)
Response to levetiracetam in genetic generalized epilepsy (
32308125
)
Stroke (
29531354
)
Interacting Genes
24 interacting genes:
ANK1
ANK2
CNTN1
CNTN2
CSNK2A1
EZR
FGFR1
ITGA5
ITGAV
LINC00839
MSN
NCAM1
NCAN
NRP1
NRP2
NUMB
PEA15
PLXNA1
PLXNB1
PRNP
RANBP9
RDX
RPS6KA1
RPS6KA2
20 interacting genes:
ANKRD28
DNAJB1
DNAJB5
ECPAS
EPB42
GABARAP
GABARAPL1
GABARAPL2
L1CAM
MAP1LC3A
MAP1LC3B
MAP1LC3C
NDEL1
NRCAM
OBSCN
SIGMAR1
SPTBN1
TAF9
TNIK
TP53
Entrez ID
3897
287
HPRD ID
02394
00110
Ensembl ID
ENSG00000198910
ENSG00000145362
Uniprot IDs
P32004
Q01484
PDB IDs
4D8O
4RLV
4RLY
5Y4D
5Y4E
5Y4F
5YIR
5YIS
6KZJ
6M3Q
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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