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NRP2 and PGF
Data Source:
HPRD
(in vivo)
NRP2
PGF
Description
neuropilin 2
placental growth factor
Image
GO Annotations
Cellular Component
Semaphorin Receptor Complex
Extracellular Region
Plasma Membrane
Membrane
Integral Component Of Membrane
Axon
Glutamatergic Synapse
Integral Component Of Postsynaptic Membrane
Extracellular Region
Extracellular Space
Membrane
Molecular Function
Vascular Endothelial Growth Factor-activated Receptor Activity
Protein Binding
Heparin Binding
Semaphorin Receptor Activity
Growth Factor Binding
Cytokine Binding
Signaling Receptor Activity
Metal Ion Binding
Vascular Endothelial Growth Factor Receptor Binding
Protein Binding
Growth Factor Activity
Heparin Binding
Chemoattractant Activity
Biological Process
Angiogenesis
Positive Regulation Of Endothelial Cell Proliferation
Outflow Tract Septum Morphogenesis
Cell Adhesion
Axon Guidance
Positive Regulation Of Endothelial Cell Migration
Viral Process
Facial Nerve Structural Organization
Vestibulocochlear Nerve Structural Organization
Nerve Development
Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus
Ventral Trunk Neural Crest Cell Migration
Vascular Endothelial Growth Factor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Axon Extension Involved In Axon Guidance
Negative Chemotaxis
Sympathetic Ganglion Development
Trigeminal Ganglion Development
Sensory Neuron Axon Guidance
Sympathetic Neuron Projection Extension
Sympathetic Neuron Projection Guidance
Regulation Of Postsynapse Organization
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance
Facioacoustic Ganglion Development
Dorsal Root Ganglion Morphogenesis
Cellular Response To Leukemia Inhibitory Factor
Response To Hypoxia
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Sprouting Angiogenesis
Signal Transduction
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Cell Differentiation
Vascular Endothelial Growth Factor Signaling Pathway
Positive Regulation Of Angiogenesis
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Chemotaxis
Induction Of Positive Chemotaxis
Positive Regulation Of Cell Division
Positive Regulation Of Mast Cell Chemotaxis
Pathways
Neurophilin interactions with VEGF and VEGFR
NrCAM interactions
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization
Drugs
Aflibercept
Diseases
GWAS
Blood protein levels (
30072576
29875488
)
Craniofacial microsomia (
26853712
)
Diisocyanate-induced asthma (
25918132
)
Neuropathy x type 2 diabetes interaction (
32541925
)
Blood protein levels (
30072576
)
Blood protein levels in cardiovascular risk (
28369058
)
Mood instability (
29187730
)
Refractive error (
32231278
)
Interacting Genes
11 interacting genes:
FLT1
L1CAM
NRP1
PGF
PLXNA1
PLXNB1
SEMA3B
SEMA3C
SEMA3F
SEMA4F
VEGFA
4 interacting genes:
FLT1
NRP1
NRP2
VEGFA
Entrez ID
8828
5228
HPRD ID
03643
03076
Ensembl ID
ENSG00000118257
ENSG00000119630
Uniprot IDs
O60462
Q7Z3T9
G3XA84
P49763
Q53XY6
Q86TW6
PDB IDs
2QQJ
2QQK
2QQL
2QQO
4QDQ
4QDR
4QDS
5DN2
5DQ0
6GH8
1FZV
1RV6
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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