ANK2 and EPB42

Data Source:
BioGRID (pull down)

		ANK2	EPB42
Description		ankyrin 2	erythrocyte membrane protein band 4.2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Lysosome Early Endosome Cytosol Cytoskeleton Plasma Membrane Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Z Disc T-tubule M Band A Band Sarcolemma Neuron Projection Costamere Postsynaptic Membrane Recycling Endosome	Cytoskeleton Plasma Membrane Cortical Cytoskeleton
	Molecular Function	Protein Binding Cytoskeletal Anchor Activity Enzyme Binding Protein Kinase Binding Spectrin Binding Protein-macromolecule Adaptor Activity Ion Channel Binding ATPase Binding Phosphorylation-dependent Protein Binding	Protein-glutamine Gamma-glutamyltransferase Activity Structural Constituent Of Cytoskeleton Protein Binding ATP Binding
	Biological Process	Regulation Of Heart Rate Atrial Septum Development Cellular Calcium Ion Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endocytosis Positive Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Protein Transport Regulation Of Protein Stability T-tubule Organization Protein Localization To Organelle Protein Localization To Cell Surface Cellular Protein Localization Protein Localization To M-band Protein Localization To T-tubule Positive Regulation Of Potassium Ion Transport Protein Stabilization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sarcoplasmic Reticulum Calcium Ion Transport Protein Localization To Endoplasmic Reticulum Protein Localization To Plasma Membrane Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of SA Node Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Cation Channel Activity	Cell Morphogenesis Cytoskeleton Organization Regulation Of Cell Shape Peptide Cross-linking Protein Phosphopantetheinylation Hemoglobin Metabolic Process Erythrocyte Maturation Spleen Development Iron Ion Homeostasis
Pathways		Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins COPI-mediated anterograde transport
Drugs
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)	Hereditary spherocytosis (SPH)
GWAS		Blood trace element (Cu levels) ( 23720494) Body mass index ( 26426971) Chronotype ( 30696823) Diastolic blood pressure ( 31469255) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Coprococcus) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Ischemic stroke ( 29531354) Parkinson's disease ( 28892059) Periventricular white matter hyperintensities ( 32517579) Response to levetiracetam in genetic generalized epilepsy ( 32308125) Stroke ( 29531354)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		20 interacting genes: ANKRD28 DNAJB1 DNAJB5 ECPAS EPB42 GABARAP GABARAPL1 GABARAPL2 L1CAM MAP1LC3A MAP1LC3B MAP1LC3C NDEL1 NRCAM OBSCN SIGMAR1 SPTBN1 TAF9 TNIK TP53	13 interacting genes: ANK1 ANK2 BLOC1S4 CD47 DMTN EPB41 KRAS MAPK14 SLC4A1 SLC4A2 SPINK7 SPTAN1 STX12
Entrez ID		287	2038
HPRD ID		00110	01517
Ensembl ID		ENSG00000145362	ENSG00000166947
Uniprot IDs		Q01484	P16452
PDB IDs		4D8O 4RLV 4RLY 5Y4D 5Y4E 5Y4F 5YIR 5YIS 6KZJ 6M3Q
Enriched GO Terms of Interacting Partners?
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