ITK and GAB1

Data Source:
BioGRID (pull down)

		ITK	GAB1
Description		IL2 inducible T cell kinase	GRB2 associated binding protein 1
Image
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cell-cell Junction	Cytosol Cell-cell Junction
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Binding
	Biological Process	Cytokine Production NK T Cell Differentiation Adaptive Immune Response Cellular Defense Response Signal Transduction Activation Of Phospholipase C Activity Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway T Cell Activation Gamma-delta T Cell Activation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Insulin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Cytoskeleton Reorganization Response To Hepatocyte Growth Factor Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway ERBB2 Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Protein Kinase B Signaling Endothelial Cell Chemotaxis To Vascular Endothelial Growth Factor
Pathways		Generation of second messenger molecules FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	PI3K Cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PIP3 activates AKT signaling GAB1 signalosome PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer RET signaling MET activates PTPN11 MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants
Drugs		Staurosporine Pazopanib Fostamatinib Zanubrutinib
Diseases
GWAS		Asthma ( 31959851) Daytime sleep phenotypes ( 27126917) Eosinophil counts ( 32888494) Heel bone mineral density ( 30598549) Personality traits in bipolar disorder ( 21368711) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)	Asthma ( 21804548) Diastolic blood pressure ( 27841878) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate in non-diabetics ( 31451708) Height ( 31562340) Malaria ( 31844061) Systolic blood pressure ( 27841878) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		34 interacting genes: BLNK BMX BTK CBL CD28 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FGFR1 FYN GAB1 GRB2 HNRNPK IKBKG KHDRBS1 KPNA2 LAT LCK LCP2 MET PLCG1 PLCG2 PPIA SH2D2A SMAD4 SMURF1 SOCS1 SPRR2A SRC TGFBR1 WAS	73 interacting genes: ARHGAP32 BCAR3 BLK BLNK BTK C1QBP CRK CRKL EGFR EPOR ERBB2 FCGR2B FES FRS2 GAB2 GRAP2 GRB2 GTF2A1L HCK HSH2D INPP5D INPPL1 INSR ITK JAK1 LAT2 LCK LYN MAP3K3 MAPK1 MAPK3 MAPK4 MARK2 MET MST1R NCK1 NCK2 PDGFRB PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PTK6 PTPN11 PTPN18 RASA1 RET SH2D1B SH2D2A SH2D3A SHC1 SHC3 SLA SLA2 SOCS3 SOCS6 SOS1 SRC STAP1 SUPT6H SYK SYP TEC TNS1 TNS3 TNS4 TRIM15 VAV1 VAV2 VAV3 YES1
Entrez ID		3702	2549
HPRD ID		01746	05116
Ensembl ID		ENSG00000113263	ENSG00000109458
Uniprot IDs		Q08881	Q13480 Q9HA84
PDB IDs		1SM2 1SNU 1SNX 2E6I 2LMJ 2YUQ 3MIY 3MJ1 3MJ2 3QGW 3QGY 3T9T 3V5J 3V5L 3V8T 3V8W 4HCT 4HCU 4HCV 4KIO 4L7S 4M0Y 4M0Z 4M12 4M13 4M14 4M15 4MF0 4MF1 4PP9 4PPA 4PPB 4PPC 4PQN 4QD6 4RFM	4QSY
Enriched GO Terms of Interacting Partners?
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