GAB1 and PIK3R3

GAB1

PIK3R3

Description GRB2 associated binding protein 1 phosphoinositide-3-kinase regulatory subunit 3
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Asthma ( 21804548)
  • Diastolic blood pressure ( 27841878)
  • Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
  • Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
  • Estimated glomerular filtration rate in non-diabetics ( 31451708)
  • Height ( 31562340)
  • Malaria ( 31844061)
  • Systolic blood pressure ( 27841878)
  • Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
  • Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
  • Body mass index ( 26426971 28448500)
  • Body mass index (joint analysis main effects and physical activity interaction) ( 28448500)
  • Body mass index in physically active individuals ( 28448500)
  • Brain morphology (min-P) ( 32665545)
  • Brain morphology (MOSTest) ( 32665545)
  • Breast cancer ( 29059683)
  • Cortical surface area (min-P) ( 32665545)
  • Cortical surface area (MOSTest) ( 32665545)
  • Cortical thickness (min-P) ( 32665545)
  • Cortical thickness (MOSTest) ( 32665545)
  • Diastolic blood pressure ( 30224653)
  • Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
  • Estimated glomerular filtration rate ( 31152163)
  • Lymphocyte percentage of white cells ( 32888494)
  • Metabolite levels ( 23823483)
  • Neutrophil count ( 32888494)
  • Neutrophil percentage of white cells ( 32888494)
  • Red cell distribution width ( 32888494)
  • Sodium levels ( 29403010)
  • Subcortical volume (min-P) ( 32665545)
  • Subcortical volume (MOSTest) ( 32665545)
  • Sum neutrophil eosinophil counts ( 27863252)
  • White blood cell count ( 32888494 27863252)
Interacting Genes 73 interacting genes: ARHGAP32 BCAR3 BLK BLNK BTK C1QBP CRK CRKL EGFR EPOR ERBB2 FCGR2B FES FRS2 GAB2 GRAP2 GRB2 GTF2A1L HCK HSH2D INPP5D INPPL1 INSR ITK JAK1 LAT2 LCK LYN MAP3K3 MAPK1 MAPK3 MAPK4 MARK2 MET MST1R NCK1 NCK2 PDGFRB PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PTK6 PTPN11 PTPN18 RASA1 RET SH2D1B SH2D2A SH2D3A SHC1 SHC3 SLA SLA2 SOCS3 SOCS6 SOS1 SRC STAP1 SUPT6H SYK SYP TEC TNS1 TNS3 TNS4 TRIM15 VAV1 VAV2 VAV3 YES1 124 interacting genes: ABCB6 ABL2 AMBP ANKS1A ANTKMT AR ARID4B AUNIP AXL BLK BLZF1 BRK1 BTK C3orf36 C9orf24 CAMK1 CCDC14 CCDC196 CCDC33 CCDC89 CEP126 CEP19 CHRDL2 CLNK CRBN CRK DARS1 DCAF8 DISC1 DRAP1 DSN1 E2F6 EGFR ENKD1 ERBB2 ERBB3 ERBB4 ESR1 FAM166B FBN3 FER FGB FNDC8 FOXO1 FSD2 FYN GAB1 GC GRB2 HROB HSH2D IGF1R INSR IQUB IRS1 IRS2 ITGB3BP KARS1 KHDRBS1 KIAA0408 KIT KLC2 KLF15 KMT2B L3MBTL3 LAP3 LNX2 LUC7L2 MBIP MECOM MET MICAL1 MTF2 NAB2 NCK1 NEBL NEDD9 ORM1 PACRGL PBX4 PCDHB5 PDGFRB PELO PIK3CA PIK3CD PLAAT4 PLB1 PLEKHF2 PPARA PRKAR1B PSME1 PTK2 QARS1 RB1 RING1 RUSC1 SERF1A SERTAD2 SOCS6 SPATA32 SRC SSBP4 STAT3 STAT5B TASOR2 TEC TERF2 TNK2 TNNC2 TNNI1 TRIM54 TRMT2A TSPAN2 USP2 VBP1 VCP WRNIP1 YES1 YPEL3 ZBTB18 ZMAT1 ZNF281 ZNF451 ZNF620
Entrez ID 2549 8503
HPRD ID 05116 05831
Ensembl ID ENSG00000109458 ENSG00000117461
Uniprot IDs Q13480 Q9HA84 B4DXM8 Q68CY7 Q7Z3W2 Q8N381 Q92569
PDB IDs 4QSY
Enriched GO Terms of Interacting Partners?
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