ITK and BMX

Data Source:
HPRD (in vitro)

		ITK	BMX
Description		IL2 inducible T cell kinase	BMX non-receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cell-cell Junction	Nucleoplasm Cytosol Plasma Membrane Ruffle Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Cytokine Production NK T Cell Differentiation Adaptive Immune Response Cellular Defense Response Signal Transduction Activation Of Phospholipase C Activity Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway T Cell Activation Gamma-delta T Cell Activation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Adaptive Immune Response Protein Phosphorylation Phosphatidylinositol Biosynthetic Process Apoptotic Process Cell Adhesion Signal Transduction Mesoderm Development Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Protein Autophosphorylation B Cell Receptor Signaling Pathway
Pathways		Generation of second messenger molecules FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	Apoptotic cleavage of cellular proteins Synthesis of PIPs at the plasma membrane
Drugs		Staurosporine Pazopanib Fostamatinib Zanubrutinib	Fostamatinib Zanubrutinib
Diseases
GWAS		Asthma ( 31959851) Daytime sleep phenotypes ( 27126917) Eosinophil counts ( 32888494) Heel bone mineral density ( 30598549) Personality traits in bipolar disorder ( 21368711) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)
Interacting Genes		34 interacting genes: BLNK BMX BTK CBL CD28 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FGFR1 FYN GAB1 GRB2 HNRNPK IKBKG KHDRBS1 KPNA2 LAT LCK LCP2 MET PLCG1 PLCG2 PPIA SH2D2A SMAD4 SMURF1 SOCS1 SPRR2A SRC TGFBR1 WAS	26 interacting genes: APP BCAR1 BIRC2 BTK CASP3 CAV1 CLNK EGFR ERBB2 FBXO25 ITK KDR NOPCHAP1 PAK1 PTK2 PTPN21 PTPRD RAP1A RUFY1 RUFY2 SRC STAT1 STAT3 STAT5A TEC TNFRSF1B
Entrez ID		3702	660
HPRD ID		01746	02111
Ensembl ID		ENSG00000113263	ENSG00000102010
Uniprot IDs		Q08881	P51813
PDB IDs		1SM2 1SNU 1SNX 2E6I 2LMJ 2YUQ 3MIY 3MJ1 3MJ2 3QGW 3QGY 3T9T 3V5J 3V5L 3V8T 3V8W 4HCT 4HCU 4HCV 4KIO 4L7S 4M0Y 4M0Z 4M12 4M13 4M14 4M15 4MF0 4MF1 4PP9 4PPA 4PPB 4PPC 4PQN 4QD6 4RFM	2EKX 2YS2 3SXR 3SXS 6I99
Enriched GO Terms of Interacting Partners?
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